Evidence map›Paper›PMID 21388439›Full record

ReviewFEMS microbiology letters2011

Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes.

Nathalie T Reichmann, Angelika Gründling

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS microbiology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 202 citations in OpenAlex.

  1. Infection and immunity · 2026
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  2. A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  3. Review
  4. Enhancement of low-temperature growth ofbioRxiv : the preprint server for biology · 2026
    Article
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  6. ThemBio · 2025
    Article
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  14. Science advances · 2024
    Article
  15. Review
  16. Article
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  18. Review
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nathalie T ReichmannSection of Microbiology, Imperial College London, South Kensington Campus, London, UK.
Angelika Gründling
Imperial College London · GB

Funding

European Research Council 260371Medical Research Council G0701212Wellcome TrustWellcome Trust WT084483
6 · The paper itself

Abstract

Lipoteichoic acid (LTA) is a zwitterionic polymer found in the cell wall of many Gram-positive bacteria. A widespread and one of the best-studied forms of LTA consists of a polyglycerolphosphate (PGP) chain that is tethered to the membrane via a glycolipid anchor. In this review, we will summarize our current understanding of the enzymes involved in glycolipid and PGP backbone synthesis in a variety of different Gram-positive bacteria. The recent identification of key LTA synthesis proteins allowed the construction and analysis of mutant strains with defined defects in glycolipid or backbone synthesis. Using these strains, new information on the functions of LTA for bacterial growth, physiology and during developmental processes was gained and will be discussed. Furthermore, we will reintroduce the idea that LTA remains in close proximity to the bacterial membrane for its function during bacterial growth rather than as a surface-exposed structure.

Indexed as

Bacterial ProteinsGlycerophosphatesGlycolipidsGram-Positive BacteriaLipopolysaccharidesTeichoic AcidsBacterial ProteinsGlycerophosphatesGlycolipidsLipopolysaccharideslipoteichoic acidpolyglycerolphosphateTeichoic Acids

Identifiers

PMID21388439
PMCPMC3089915
OpenAlexW1916574382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.