ArticleJournal of medicinal chemistry2011
Synthetic mimics of antimicrobial peptides from triaryl scaffolds.
Article in Journal of medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Polyacrylamide-Based Antimicrobial Copolymers to Replace or Rescue Antibiotics.ACS central science · 2025Article
- Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers.Frontiers in microbiology · 2022Review
- Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G.Probiotics and antimicrobial proteins · 2021Article
- Detection of bacteria using antimicrobial polymer derived via ring-opening metathesis (romp) pathway.Turkish journal of chemistry · 2021Article
- Challenges in the development of next-generation antibiotics: opportunities of small molecules mimicking mode of action of host-defense peptides.Expert opinion on therapeutic patents · 2020Article
- Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane.European journal of medicinal chemistry · 2018Article
- Synthesis and Bioactivity of Polymer-Based Synthetic Mimics of Antimicrobial Peptides (SMAMPs) Made from Asymmetrically Disubstituted Itaconates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.Molecules (Basel, Switzerland) · 2017Review
- Optimal Hydrophobicity in Ring-Opening Metathesis Polymerization-Based Protein Mimics Required for siRNA Internalization.Biomacromolecules · 2016Article
- Design and Application of Antimicrobial Peptide Conjugates.International journal of molecular sciences · 2016Review
- Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells ofFrontiers in microbiology · 2016Article
- Development of protein mimics for intracellular delivery.Biopolymers · 2015Review
- Design of aromatic-containing cell-penetrating peptide mimics with structurally modified π electronics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Designing mimics of membrane active proteins.Accounts of chemical research · 2013Article
- Polymeric systems of antimicrobial peptides--strategies and potential applications.Molecules (Basel, Switzerland) · 2013Review
- Expedient Synthesis of SMAMPs via Click Chemistry.ACS medicinal chemistry letters · 2013Article
- Synthetic mimics of antimicrobial peptides with immunomodulatory responses.Journal of the American Chemical Society · 2012Article
- Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?International journal of antimicrobial agents · 2011Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 μg/mL against S. Aureus and 6.25 μg/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.