ArticleProceedings of the National Academy of Sciences of the United States of America1990
Genomic organization of mouse Fc gamma receptor genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Evolution of Fc Receptor-Like Scavenger in Mammals.Frontiers in immunology · 2020Article
- Identification of a family of Fc receptor homologs with preferential B cell expression.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells.Clinical and experimental immunology · 1997Article
- Fc gamma receptors: gene structure and receptor function.Immunologic research · 1992Article
- Regulation of the expression of murine alpha- and beta-Fc gamma R genes.Immunologic research · 1992Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We have isolated and characterized the gene coding for the mouse Fc receptor that is termed Fc gamma RIIa. The gene contains five exons and spans approximately 9 kilobases. Unlike most members of the immunoglobulin gene superfamily, this gene utilizes multiple exons to encode its leader peptide. The first exon encodes the hydrophobic region of the signal sequence; the second exon, which contains only 21 base pairs, encodes a segment of the signal peptidase recognition site; and the beginning of the third exon encodes the predicted site of peptidase cleavage. The third and fourth exons each code for immunoglobulin-like extracellular domains. The fifth exon encodes the hydrophobic transmembrane domain and the cytoplasmic tail. Partial characterization of the Fc gamma RIIb gene indicates that it also contains multiple leader exons, including a 21-base-pair exon and two exons coding for homologous immunoglobulin-like extracellular domains. However, the Fc gamma RIIb gene uses four exons to encode its intracytoplasmic region. Analysis using contour-clamped homogeneous electric field (CHEF) gels indicates that the Fc gamma RIIa and Fc gamma RIIb genes are linked within 160 kilobases on mouse chromosome 1.
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