ArticleAnnals of neurology2011
Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease.
Article in Annals of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Mediterranean diet and dementia: MRI marker evidence from meta-analysis.European journal of medical research · 2025Pooled it
- The Impact of the Mediterranean Diet on the Cognitive Functioning of Healthy Older Adults: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2016Pooled it
- MIND diet, cerebrovascular health, and cognition among community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Mediterranean diet and cardiovascular disease.Cardiovascular research · 2025Review
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Decline in Incidence and Prevalence of Dementia: An Analysis of Outpatient Claims Data.Deutsches Arzteblatt international · 2025Observational
- Diets to promote healthy brain ageing.Nature reviews. Neurology · 2025Review
- The Relationship Between Dietary Patterns, Cognition, and Cardiometabolic Health in Healthy, Older Adults.Nutrients · 2024Observational
- Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.Frontiers in medicine · 2024Review
- Prevention of Alzheimer's disease through diet: An exploratory review.Metabolism open · 2023Review
- The association of MIND diet with cognitive resilience to neuropathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults.Nutrients · 2022Article
- Review
- Mediterranean Diet and its Effects on Silent Brain Infarcts in a Cohort of Patients With Atrial Fibrillation.Nutrition and metabolic insights · 2022Article
- Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2022Article
- Associations Between Dietary Patterns and Neuroimaging Markers: A Systematic Review.Frontiers in nutrition · 2022Review
- Anti-inflammatory and Anti-oxidant Activity of HidroxAntioxidants (Basel, Switzerland) · 2020Article
- Flavonoid Intake and MRI Markers of Brain Health in the Framingham Offspring Cohort.The Journal of nutrition · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveCerebrovascular disease is 1 of the possible mechanisms of the previously reported relationship between Mediterranean-type diet (MeDi) and Alzheimer's disease (AD). We sought to investigate the association between MeDi and MRI infarcts.
methodsHigh-resolution structural MRI was collected on 707 elderly 65 years or older community residents of New York with available dietary assessments administered an average of 5.8 years (3.22 standard deviations [SDs]) before the MRI. Participants were divided into 3 groups of adherence to MeDi (low, middle, and high tertiles). We examined the association of increasing adherence to MeDi with presence of infarcts on MRI. Models were run without adjustment, adjusted for basic demographic and clinical factors, and adjusted for vascular risk factors.
resultsA total of 222 participants had at least 1 infarct. In the unadjusted model, compared to the low adherence group, those in the moderate MeDi adherence group had a 22% reduced odds of having an infarct (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.55-1.14), while participants in the highest MeDi adherence group had a 36% reduced odds (OR, 0.64; 95% CI, 0.42-0.97; p for trend = 0.04). In adjusted models, the association between MeDi adherence and MRI infarcts remained essentially unchanged. The association of high MeDi adherence with infarcts was comparable to that of hypertension (40% reduced probability), did not vary by infarct size or after excluding patients with dementia (n = 46) or clinical strokes (n = 86). There was no association between MeDi and white matter hyperintensities.
interpretationHigher adherence to the MeDi is associated with reduced cerebrovascular disease burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.