ArticleInternational journal of cancer2012
Analysis of retinoblastoma age incidence data using a fully stochastic cancer model.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Minimum latency effects for cancer associated with exposures to radiation or other carcinogens.British journal of cancer · 2024Article
- Antitumoral Potential of the Histone Demethylase Inhibitor GSK-J4 in Retinoblastoma.Investigative ophthalmology & visual science · 2024Article
- Second hit impels oncogenesis of retinoblastoma in patient-induced pluripotent stem cell-derived retinal organoids: direct evidence for Knudson's theory.PNAS nexus · 2022Article
- Article
- Review
- Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children's Oncology Group.Occupational and environmental medicine · 2018Article
- Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group.American journal of ophthalmology · 2017Article
- Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer.PLoS computational biology · 2017Article
- Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma.PloS one · 2015Article
- Breast cancer risk after radiotherapy for heritable and non-heritable retinoblastoma: a US-UK study.British journal of cancer · 2014Article
- Sarcomas in hereditary retinoblastoma.Clinical sarcoma research · 2012Article
- Variation of second cancer risk by family history of retinoblastoma among long-term survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Liquid Biopsy and Ocular Tumors: A Review.Journal of current ophthalmologyReview
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6 authors.
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Abstract
Retinoblastoma (RB) is an important ocular malignancy of childhood. It has been commonly accepted for some time that knockout of the two alleles of the RB1 gene is the principal molecular target associated with the occurrence of RB. In this article, we examine the validity of the two-hit theory for RB by comparing the fit of a stochastic model with two or more mutational stages. Unlike many such models, our model assumes a fully stochastic stem cell compartment, which is crucial to its behavior. Models are fitted to a population-based dataset comprising 1,553 cases of RB for the period 1962-2000 in Great Britain (England, Scotland and Wales). The population incidence of RB is best described by a fully stochastic model with two stages, although models with a deterministic stem cell compartment yield equivalent fit; models with three or more stages fit much less well. The results strongly suggest that knockout of the two alleles of the RB1 gene is necessary and may be largely sufficient for the development of RB, in support of Knudson's two-hit hypothesis.
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