ArticleInternational journal of cancer2012
Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Cyclin D1 (CCND1) G870A polymorphisms and cervical cancer susceptibility: a meta-analysis based on ten case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- TMC7 promotes colorectal cancer metastasis via inhibition of PKN2 and regulation of hypoxia-adaptive responses.Translational oncology · 2026Article
- Transmembrane channel-like 5 drives hepatocellular carcinoma progression by regulating epithelial-mesenchymal transition.World journal of clinical oncology · 2025Article
- The transmembrane channel-like 6 (TMC6) in primary sensory neurons involving thermal sensation via modulating M channels.Frontiers in pharmacology · 2024Article
- Comprehensive analysis of the prognosis and immune infiltration of TMC family members in renal clear cell carcinoma.Scientific reports · 2023Article
- Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis.Clinical epigenetics · 2023Article
- RIPK3 modulates sarcoma through immune checkpoint HAVCR2.Oncology letters · 2022Article
- Risk of penile tumor development in Caucasian individuals is independent of the coding variant rs7208422 in the TMC8 (EVER2) gene.Molecular and clinical oncology · 2021Article
- Comprehensive co-expression analysis reveals TMC8 as a prognostic immune-associated gene in head and neck squamous cancer.Oncology letters · 2021Article
- Pan-Cancer Analysis Reveals the Signature of TMC Family of Genes as a Promising Biomarker for Prognosis and Immunotherapeutic Response.Frontiers in immunology · 2021Article
- TMC5 is Highly Expressed in Human Cancers and Corelates to Prognosis and Immune Cell Infiltration: A Comprehensive Bioinformatics Analysis.Frontiers in molecular biosciences · 2021Article
- Genetic variations in theOncology letters · 2018Article
- mRNA expression profiles obtained from microdissected pancreatic cancer cells can predict patient survival.Oncotarget · 2017Article
- Transmembrane channel-like protein 8 as a potential biomarker for poor prognosis of hepatocellular carcinoma.Molecular and clinical oncology · 2017Article
- Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study.BMC cancer · 2016Article
- The EVER genes - the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients.Postepy dermatologii i alergologii · 2016Review
- Genetic variations in the epidermodysplasia verruciformis (EVER/TMC) genes, cutaneous human papillomavirus infection and squamous cell carcinoma of the skin.The British journal of dermatology · 2015Article
- A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.PloS one · 2015Article
- The transmembrane channel-like protein family and human papillomaviruses: Insights into epidermodysplasia verruciformis and progression to squamous cell carcinoma.Oncoimmunology · 2014Article
- The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines.Virology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Cervical cancer (CxCa) is caused by persistent human papillomavirus (HPV) infection; genetic predisposition is also suspected to play a role. Our study is a targeted candidate gene follow-up based on: (i) strong clinical evidence demonstrating that mutations in the TMC6 and TMC8 (EVER1 and EVER2) genes associate with the HPV-associated disease epidermodysplasia verruciformis (EV) and (ii) recent epidemiological data suggesting a genetic susceptibility conferred by polymorphisms in such genes for skin and CxCa. Clarifying the association of the TMC6/8 genes with risk of CxCa will help in understanding why some HPV-infected women develop persistent infection, cervical lesions and eventually cancer while others do not. Twenty-two single nucleotide polymorphisms (SNPs) harboring the TMC6/8 genes were genotyped in 2,989 cases with cervical intraepithelial neoplasia grade III or invasive CxCa and 2,281 controls from the Swedish population. Association was evaluated in logistic regression models. Two SNPs displayed association with cervical disease: rs2290907 [odds ratio (OR)(GGvsAA) = 0.6, 95% confidence interval (95% CI): 0.3-0.9, p = 0.02)] and rs16970849 (OR(AGvsGG) = 0.8, 95% CI: 0.66-0.98, p = 0.03). The present data support the involvement of the TMC6/8 region in CxCa susceptibility but further analyses are needed to replicate our findings, fully characterize the region and understand the function of the genetic variants involved.
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