ArticleCellular and molecular life sciences : CMLS2012
The role of LamininB2 (LanB2) during mesoderm differentiation in Drosophila.
Article in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
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- Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces.Journal of cell science · 2025Article
- Thrombospondins: Conserved mediators and modulators of metazoan extracellular matrix.International journal of experimental pathology · 2024Review
- The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila.Development (Cambridge, England) · 2023Article
- Basement membrane dynamics and mechanics in tissue morphogenesis.Biology open · 2023Review
- Epithelial Cell Polarity DuringFrontiers in cell and developmental biology · 2022Review
- Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins.The Journal of cell biology · 2021Article
- LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration inFrontiers in cell and developmental biology · 2021Article
- Spatial and morphological reorganization of endosymbiosis during metamorphosis accommodates adult metabolic requirements in a weevil.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Analysis of extracellular matrix composition in the visceral muscles ofmicroPublication biology · 2020Article
- Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis.Scientific reports · 2019Article
- Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation.Cell · 2019Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Drosophila Embryonic Hemocytes Produce Laminins to Strengthen Migratory Response.Cell reports · 2017Article
- Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- Dissecting the Role of the Extracellular Matrix in Heart Disease: Lessons from the Drosophila Genetic Model.Veterinary sciences · 2017Review
- Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, four genes encode for laminin subunits and the formation of two laminin heterotrimers has been postulated. We report the identification of mutations in the Drosophila LamininB2 (LanB2) gene that encodes for the only laminin γ subunit and is found in both heterotrimers. We describe their effects on embryogenesis, in particular the differentiation of visceral tissues with respect to the ECM. Analysis of mesoderm endoderm interaction indicates disrupted basement membranes and defective endoderm migration, which finally interferes with visceral myotube stretching. Extracellular deposition of laminin is blocked due to the loss of the LanB2 subunit, resulting in an abnormal distribution of ECM components. Our data, concerning the different function of both trimers during organogenesis, suggest that these trimers might act in a cumulative way and probably at multiple steps during ECM assembly. We also observed genetic interactions with kon-tiki and thrombospondin, indicating a role for laminin during muscle attachment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.