ReviewCellular and molecular life sciences : CMLS2011
Insights into MHC class I antigen processing gained from large-scale analysis of class I ligands.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- A conceptual blueprint for "turning cold to hot" in Osteosarcoma: from TME stratification hypotheses to adaptive therapeutic prospects.Cell communication and signaling : CCS · 2026Review
- BERTrand-peptide:TCR binding prediction using Bidirectional Encoder Representations from Transformers augmented with random TCR pairing.Bioinformatics (Oxford, England) · 2023Article
- Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE).Proteomics · 2018Article
- Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy.Cellular and molecular life sciences : CMLS · 2018Review
- Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.PLoS computational biology · 2017Article
- MHC class I-associated peptides derive from selective regions of the human genome.The Journal of clinical investigation · 2016Article
- Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.International journal of molecular sciences · 2016Article
- ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.Nature communications · 2016Article
- Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry.Molecular & cellular proteomics : MCP · 2015Review
- Protein networks and activation of lymphocytes.Current opinion in immunology · 2015Review
- Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome.PloS one · 2015Article
- Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).Nature reviews. Immunology · 2014Review
- Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.Nature communications · 2014Article
- Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD).Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Increased diversity of the HLA-B40 ligandome by the presentation of peptides phosphorylated at their main anchor residue.Molecular & cellular proteomics : MCP · 2014Article
- Dipeptides promote folding and peptide binding of MHC class I molecules.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The effect of proteasome inhibition on the generation of the human leukocyte antigen (HLA) peptidome.Molecular & cellular proteomics : MCP · 2013Article
- The human leukocyte antigen-presented ligandome of B lymphocytes.Molecular & cellular proteomics : MCP · 2013Article
- Bioinformatics for cancer immunology and immunotherapy.Cancer immunology, immunotherapy : CII · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short peptides derived from intracellular proteins and presented on MHC class I molecules on the cell surface serve as a showcase for the immune system to detect pathogenic or malignant alterations inside the cell, and the sequencing and analysis of the presented peptide pool has received considerable attention over the last two decades. In this review, we give a comprehensive presentation of the methods employed for the large-scale qualitative and quantitative analysis of the MHC class I ligandome. Furthermore, we focus on insights gained into the underlying processing pathway, especially involving the roles of the proteasome, the TAP complex, and the peptide specificities and motifs of MHC molecules. The identification of post-translational modifications in MHC ligands and their implications for processing are also considered. Finally, we review the correlations of the ligandome to the proteome and the transcriptome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.