ReviewIntegrative biology : quantitative biosciences from nano to macro2011
Bioengineering approaches to study multidrug resistance in tumor cells.
Review in Integrative biology : quantitative biosciences from nano to macro, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Genetic advancements in breast cancer treatment: a review.Discover oncology · 2025Review
- Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.International journal of oncology · 2018Article
- A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics.Oncotarget · 2016Article
- Silencing MRP1-4 genes by RNA interference enhances sensitivity of human hepatoma cells to chemotherapy.American journal of translational research · 2016Article
- Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations.Biomaterials · 2014Article
- Article
- Mechanics: The forces of cancer.Nature · 2012Article
- Non-invasive imaging of PI3K/Akt/mTOR signalling in cancer.American journal of nuclear medicine and molecular imaging · 2012Article
- Alteration of cellular behavior and response to PI3K pathway inhibition by culture in 3D collagen gels.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The ability of cancer cells to become resistant to chemotherapeutic agents is a major challenge for the treatment of malignant tumors. Several strategies have emerged to attempt to inhibit chemoresistance, but the fact remains that resistance is a problem for every effective anticancer drug. The first part of this review will focus on the mechanisms of chemoresistance. It is important to understand the environmental cues, transport limitations and the cellular signaling pathways associated with chemoresistance before we can hope to effectively combat it. The second part of this review focuses on the work that needs to be done moving forward. Specifically, this section focuses on the necessity of translational research and interdisciplinary directives. It is critical that the expertise of oncologists, biologists, and engineers be brought together to attempt to tackle the problem. This discussion is from an engineering perspective, as the dialogue between engineers and other cancer researchers is the most challenging due to non-overlapping background knowledge. Chemoresistance is a complex and devastating process, meaning that we urgently need sophisticated methods to study the process of how cells become resistant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.