ArticlePloS one2011
Polysaccharides isolated from Açaí fruit induce innate immune responses.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Exploring Bioactive Polysaccharides in Edible Fruits: A Cross-Biome Perspective.Plants (Basel, Switzerland) · 2025Review
- Edible Berries- An Update on Nutritional Composition and Health Benefits-Part I.Current nutrition reports · 2025Review
- A TLR4 agonist liposome formulation effectively stimulates innate immunity and enhances protection from bacterial infection.Innate immunity · 2023Article
- Açai Berry Administration Promotes Wound Healing through Wnt/β-Catenin Pathway.International journal of molecular sciences · 2023Article
- Healthy adults supplemented with a nutraceutical formulation containingFrontiers in nutrition · 2023Article
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- Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview.Vaccines · 2020Review
- Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides fromMarine drugs · 2020Article
- The Use ofBiomolecules · 2020Review
- Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan Induces IL-10-Producing B Cells and Hinders CD4iScience · 2019Article
- Extraction of Polysaccharide fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Therapeutic Effect ofFrontiers in pharmacology · 2018Article
- Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).Phytotherapy research : PTR · 2016Review
- Houttuyniacordata Thunb. polysaccharides ameliorates lipopolysaccharide-induced acute lung injury in mice.Journal of ethnopharmacology · 2015Article
- Uncovering potential 'herbal probiotics' in Juzen-taiho-to through the study of associated bacterial populations.Bioorganic & medicinal chemistry letters · 2015Article
- Immunotherapy for tularemia.Virulence · 2013Review
- Gamma delta T cells are activated by polysaccharide K (PSK) and contribute to the anti-tumor effect of PSK.Cancer immunology, immunotherapy : CII · 2013Article
- Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.BMC complementary and alternative medicine · 2013Article
- Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.Journal of ethnopharmacology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The Açaí (Acai) fruit is a popular nutritional supplement that purportedly enhances immune system function. These anecdotal claims are supported by limited studies describing immune responses to the Acai polyphenol fraction. Previously, we characterized γδ T cell responses to both polyphenol and polysaccharide fractions from several plant-derived nutritional supplements. Similar polyphenol and polysaccharide fractions are found in Acai fruit. Thus, we hypothesized that one or both of these fractions could activate γδ T cells. Contrary to previous reports, we did not identify agonist activity in the polyphenol fraction; however, the Acai polysaccharide fraction induced robust γδ T cell stimulatory activity in human, mouse, and bovine PBMC cultures. To characterize the immune response to Acai polysaccharides, we fractionated the crude polysaccharide preparation and tested these fractions for activity in human PBMC cultures. The largest Acai polysaccharides were the most active in vitro as indicated by activation of myeloid and γδ T cells. When delivered in vivo, Acai polysaccharide induced myeloid cell recruitment and IL-12 production. These results define innate immune responses induced by the polysaccharide component of Acai and have implications for the treatment of asthma and infectious disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.