ArticleJournal of pain research2010
Topical preparations for pain relief: efficacy and patient adherence.
Article in Journal of pain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05891132 (Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery), which is not on this map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial
Who cites it
61 citing papers in PubMed, 193 citations in OpenAlex.
- Trial
- Trachyspermum ammi 10 % topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Trial
- A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Trial
- A Topical Botanical Ointment for Self-Reported Hip and/or Knee Pain: A Randomized Placebo-Controlled Clinical Trial.Journal of evidence-based integrative medicineTrial
- Study of Ex Vivo and In Vivo Effect of Topical Ionic Solution of Diclofenac Sodium in Male Albino Rats Using Iontophoretic Technique.Advances in pharmacological and pharmaceutical sciences · 2026Article
- Article
- Challenges, Unmet Needs, and Future Directions for Nanocrystals in Dermal Drug Delivery.Molecules (Basel, Switzerland) · 2025Review
- New Gel Approaches for the Transdermal Delivery of Meloxicam.Gels (Basel, Switzerland) · 2025Review
- Enhancing skin permeation of Phlai oil and ginger extracts through lipid nanoparticle encapsulation for anti-inflammatory topical products.BMC complementary medicine and therapies · 2025Article
- Metabotropic Glutamate Receptor 5: A Potential Target for Neuropathic Pain Treatment.Current neuropharmacology · 2025Review
- Optimizing Pain Management in Emergency Departments: A Comprehensive Review of Current Analgesic Practices.Cureus · 2024Review
- Why Pharmacovigilance of Non-steroidal Anti-inflammatory Drugs is Important in India?Endocrine, metabolic & immune disorders drug targets · 2024Review
- The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.Therapeutic advances in musculoskeletal disease · 2024Review
- Recent Progress in Gels for Neuropathic Pain.Gels (Basel, Switzerland) · 2023Review
- Effect of transversus abdominis plane block with or without buprenorphine after inguinal hernia surgery on postoperative pain.Anaesthesiology intensive therapy · 2023Article
- Effects of Warm Needle Acupuncture plus Xitong Waixi Lotion in Patients with Knee Osteoarthritis: A Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Optimization of Influential Variables in the Development of Buprenorphine and Bupivacaine Loaded Invasome for Dermal Delivery.Advanced pharmaceutical bulletin · 2021Article
- Cannabidiol (CBD) and other drug use among young adults who use cannabis in Los Angeles.Drug and alcohol dependence · 2021Article
- Meloxicam emulgels for topical management of rheumatism: Formulation development,Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions.Pharmaceutics · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been an increasing focus on development of new routes of drug administration to provide tailored treatments for patients, without decreasing efficacy of analgesia, in proportion to the progression of the knowledge of pain mechanisms. While acute pain acts as an alarm, chronic pain is a syndrome requiring meticulous selection of analgesic drugs of high bioavailability for long-term use. Such criteria are challenges that topical medications aim to overcome, allowing progressive delivery of active component, maintaining stable plasma levels, with a good safety profile. This review presents recent findings regarding topical formulations of the most widely used drugs for pain treatment, such as nonsteroidal anti-inflammatory agents, anesthetics, and capsaicin, and the role of physical agents as delivery enhancers (phonophoresis and iontophoresis). Although the number of topical agents is limited for use in peripheral conditions, increasing evidence supports the efficacy of these preparations in blocking nociceptive and neuropathic pain. Patient adherence to medical treatment is also a challenge, especially in chronic painful conditions. It is known that reduction of treatment complexity and pill burden are good strategies to increase patient compliance, as discussed here. However, the role of topical presentations, when compared to traditional routes, has not yet been fully explored and thus remains unclear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.