ReviewNature reviews. Gastroenterology & hepatology2011
Excess body weight and obesity--the link with gastrointestinal and hepatobiliary cancer.
Review in Nature reviews. Gastroenterology & hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk.GeroScience · 2025Pooled it
- Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.British journal of cancer · 2016Pooled it
- Microbiome dysbiosis and its modulation in cancer development, prevention and therapy.Frontiers in oncology · 2026Review
- Adipokines: masterminds of metabolic inflammation.Nature reviews. Immunology · 2025Review
- Interplay of Cardiometabolic Syndrome and Biliary Tract Cancer: A Comprehensive Analysis with Gender-Specific Insights.Cancers · 2024Review
- Weight-centric prevention of cancer.Obesity pillars · 2024Review
- Exercise suppresses tumor growth independent of high fat food intake and associated immune dysfunction.Scientific reports · 2022Article
- Understanding the Role of Metabolic Syndrome as a Risk Factor for Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2022Review
- Unrestrained eating behavior and risk of digestive system cancers: a prospective cohort study.The American journal of clinical nutrition · 2021Article
- Obesity and Pancreatic Cancer: Insight into Mechanisms.Cancers · 2021Review
- Plasma lipids, tumor parameters and survival in HCC patients with HBV and HCV.Journal of translational science · 2021Article
- Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study.International journal of cancer · 2021Article
- Baseline liver steatosis has no impact on liver metastases and overall survival in rectal cancer patients.BMC cancer · 2021Observational
- Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications.Frontiers in oncology · 2021Review
- Review
- Evidence from big data in obesity research: international case studies.International journal of obesity (2005) · 2020Article
- Impact of bariatric surgery on cancer risk reduction.Annals of translational medicine · 2020Review
- Obesity Surgery and Cancer: What Are the Unanswered Questions?Frontiers in endocrinology · 2020Review
- KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops.Seminars in cancer biology · 2019Review
- The association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.International journal of clinical and experimental pathology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Excess body weight (EBW) is an independent risk factor for many human malignancies, including cancers throughout the gastrointestinal and hepatobiliary tract from the esophagus to the colorectum. The relative risk of gastrointestinal cancer in obese individuals is approximately 1.5-2.0 times that for normal weight individuals, with organ-specific and gender-specific differences for specific cancers. The association between EBW and risk of premalignant stages of gastrointestinal carcinogenesis, such as colorectal adenoma and Barrett esophagus, is similar, implying a role for EBW during the early stages of carcinogenesis that could be relevant to preventative strategies. EBW also impacts negatively on gastrointestinal cancer outcomes. The mechanistic basis of the association between EBW and carcinogenesis remains incompletely understood. Postulated mechanisms include increased insulin and insulin-like growth factor signaling and chronic inflammation (both linked to the metabolic syndrome), as well as signaling via adipokines, such as leptin. The role of obesity-related changes in the intestinal microbiome in gastrointestinal carcinogenesis deserves further attention. Whether weight loss leads to reduced future gastrointestinal and liver cancer risk has yet to be fully explored. There is some support for the idea that weight loss negatively regulates colorectal carcinogenesis. In addition, data suggest a reduction in risk of several cancers in the first 10 years after bariatric surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.