ArticleInternational journal of obesity (2005)2012
Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity.
Article in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meal Timing, Genetics and Weight Loss in a Mediterranean Population
Meta Analysis of Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- The relationship of genetic signature for cardiometabolic risk with biomarkers of inflammatory and oxidative stress in diabetic patients.BMC endocrine disorders · 2025Article
- The interplay between nutrigenomics and low-carbohydrate ketogenic diets in personalized healthcare.Frontiers in nutrition · 2025Review
- CETP and APOA2 polymorphisms are associated with weight loss and healthy eating behavior changes in response to digital lifestyle modifications.Scientific reports · 2023Article
- Genotype-informed nutrition counselling in clinical practice.BMJ nutrition, prevention & health · 2023Article
- Dietary acid load modifies the effects of ApoA2-265 T > C polymorphism on lipid profile and serum leptin and ghrelin levels among type 2 diabetic patients.BMC endocrine disorders · 2022Article
- Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity.The American journal of clinical nutrition · 2018Article
- Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity-Related Genes.Lipids · 2017Review
- The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.Nutrition journal · 2017Article
- Gene-nutrient interactions and susceptibility to human obesity.Genes & nutrition · 2017Review
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
- APO A2 -265T/C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2016Article
- APOA2 -256T>C polymorphism interacts with saturated fatty acids intake to affect anthropometric and hormonal variables in type 2 diabetic patients.Genes & nutrition · 2015Article
- Towards a Universal Approach Based on Omics Technologies for the Quality Control of Food.BioMed research international · 2015Review
- Evaluating the association of APOA2 polymorphism with insulin resistance in adolescents.Meta gene · 2014Article
- Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations.The Journal of nutrition · 2013Article
- Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.JPEN. Journal of parenteral and enteral nutrition · 2013Article
- APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism.Cholesterol · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe interaction between apolipoprotein A-II (APOA2) m265 genotype and saturated fat for obesity traits has been more extensively demonstrated than for any other locus, but behavioural and hormonal mechanisms underlying this relationship are unexplored. In this study, we evaluated relationships between APOA2 and obesity risk with particular focus on patterns of eating and ghrelin, a hormonal regulator of food intake.
designCross-sectional study. SUBJECTS: Overweight and obese subjects (n=1225) were evaluated at baseline in five weight loss clinics in southeastern Spain.
methodsBehavioural data were assessed using a checklist of weight loss obstacles. Logistic regression models were fitted to estimate the risk of a specific behaviour associated with APOA2 genotype. Relationships between APOA2 genotype and saturated fat intakes for anthropometric traits and plasma ghrelin were evaluated by analysis of variance. To construct categorical variables to evaluate interactions, saturated fat intake was dichotomized into high and low according to the population median intake or as tertiles.
resultsHomozygous minor (CC) subjects were more likely to exhibit behaviours that impede weight loss ('Do you skip meals', odds ratio (OR)=2.09, P=0.008) and less likely to exhibit the protective behaviour of 'Do you plan meals in advance' (OR=0.64, P=0.034). Plasma ghrelin for CC subjects consuming low saturated fat was lower compared with (1) CC subjects consuming high saturated fat, (2) TT+TC carriers consuming low saturated fat and (3) TT+TC carriers consuming high saturated fat (all P<0.05).
conclusionsAPOA2 m265 genotype may be associated with eating behaviours and dietary modulation of plasma ghrelin. Expansion of knowledge of APOA2 and obesity to include modulation of specific behaviours and hormonal mediators not only broadens understanding of gene-diet interactions, but also facilitates the pragmatic, future goal of developing dietary guidelines based on genotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.