ArticlePediatric research2011
Transfusion effects on cardiomyocyte growth and proliferation in fetal sheep after chronic anemia.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Physiological response to fetal intravenous lipid emulsion in mid-gestation.Clinical science (London, England : 1979) · 2025Article
- Fetal cardiac troponin I levels decline toward birth in sheep.American journal of physiology. Heart and circulatory physiology · 2024Article
- Physiological response to fetal intravenous lipid emulsion.Clinical science (London, England : 1979) · 2024Article
- Large Animal Models for Simulating Physiology of Transfusion of Red Cell Concentrates-A Scoping Review of The Literature.Medicina (Kaunas, Lithuania) · 2022Article
- Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Functional adaptations of the coronary microcirculation to anaemia in fetal sheep.The Journal of physiology · 2016Article
- Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment.The Journal of endocrinology · 2016Review
- ANG II modulation of cardiac growth and remodeling in immature fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- How to build a healthy heart from scratch.Advances in experimental medicine and biology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic fetal anemia results in significant cardiac remodeling. The capacity to reverse these effects is unknown. We examined the effects of transfusion on cardiomyocyte adaptations after chronic anemia in fetal sheep subjected to daily hemorrhage beginning at 109-d GA (term ∼145 d). After 10 d of anemia, one group was killed for comparison with age-matched controls. A separate group of anemic fetuses was transfused with red blood cells at 119-d GA for comparison with controls at 129-d GA. Anemia significantly increased the heart-to-body weight ratio, an effect partially ameliorated after transfusion. Cardiomyocyte dimensions were similar among all groups, suggesting an absence of hypertrophy. The percentages of mono- and binucleated cardiomyocytes were similar between groups at 119-d GA, although the percentage of binucleated cells was significantly less in transfused fetuses compared with controls at 129-d GA. Protein levels of mitogen-activated protein kinases and protein kinase B were similar between controls and their respective intervention groups, except for a significant increase in phosphorylated c-Jun N-terminal kinase 1/2 in transfused fetuses. Thus, cardiomyocyte proliferation but not hypertrophy contributes to cardiac enlargement during fetal anemia. Transfusion results in slowing but not cessation of cardiac growth after anemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.