ArticleThe Journal of clinical investigation1990
Early expression of high-affinity receptor for immunoglobulin E (Fc epsilon RI) during differentiation of mouse mast cells and human basophils.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 61 citations in OpenAlex.
- Vespula spp. venom immunotherapy: basophil excitability and FcAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Developmental PBDE exposure persistently impairs mast cell function in vivo and drives sex-specific morphological and transcriptional changes in bone marrow-derived mast cells.Environmental research · 2026Article
- Mast cell function: a new vision of an old cell.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Review
- Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children.PloS one · 2012Article
- Syk expression in peripheral blood leukocytes, CD34+ progenitors, and CD34-derived basophils.Journal of leukocyte biology · 2010Article
- Interleukin-3 does not affect the differentiation of mast cells derived from human bone marrow progenitors.Immunological investigations · 2008Article
- IgE and FcepsilonRI regulation.Clinical reviews in allergy & immunology · 2005Review
- Targeted Fc2'-3-PE40 chimeric protein abolishes passive cutaneous anaphylaxis in mice.Clinical and experimental immunology · 2000Article
- Physical association between the high-affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma).Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Phenotypic characterization of stem cell factor-dependent human foetal liver-derived mast cells.Immunology · 1993Article
- Absence of immature mast cells in the skin of Ws/Ws rats with a small deletion at tyrosine kinase domain of the c-kit gene.The American journal of pathology · 1993Article
- Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand.The Journal of experimental medicine · 1992Article
- Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immediate hypersensitivity is due to the release of mediators from mast cells and basophils after the crosslinking of Fc epsilon RI. The appearance of such receptors was examined during differentiation of human and mouse bone marrow cells cultured in the presence of IL-3. As already reported, mouse bone marrow yield cultures of greater than 95% mast cells by 3 wk, whereas human bone marrow develop into cultures comprising 25% basophils by 3 wk. Here we show that transcripts for Fc epsilon RI subunits and membrane-associated receptors are apparent by 1 wk in both human and murine IL-3-dependent bone marrow cells. These cells contain few, if any, granules. The expression of transcripts and the number of receptor-positive cells continue to increase over 3 wk of culture. In parallel, a progressively larger number of cells become increasingly granulated to finally resemble either basophils or mast cells. Mature peripheral human basophils also contain transcripts for Fc epsilon RI and, therefore, may have the potential to synthesize de novo receptors. The early appearance of Fc epsilon FI during cell differentiation may be important for these cells to respond to IgE-mediated stimuli before granulation. The physiologic role of Fc epsilon RI could be to mediate lymphokine production (IL-3, IL-4, IL-6, and granulocyte/macrophage colony-stimulating factor) without inducing cellular degranulation.
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