ReviewJournal of speech, language, and hearing research : JSLHR2011
Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration.
Review in Journal of speech, language, and hearing research : JSLHR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Exploring the application of stem cell technology in treating sensorineural hearing loss.American journal of stem cells · 2024Review
- [Study on gene therapy for DPOAE and ABR threshold changes in adultLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss.Molecular therapy. Methods & clinical development · 2021Review
- Mechanism and Prevention of Spiral Ganglion Neuron Degeneration in the Cochlea.Frontiers in cellular neuroscience · 2021Review
- Supervised machine learning for automated classification of human Wharton's Jelly cells and mechanosensory hair cells.PloS one · 2021Article
- Transcription factor Isl1 is dispensable for the development of the mouse prosensory region.Cytotechnology · 2020Article
- Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals.Neural plasticity · 2020Review
- Outer Hair Cell and Auditory Nerve Function in Speech Recognition in Quiet and in Background Noise.Frontiers in neuroscience · 2017Article
- Screening of the SLC17A8 gene as a causative factor for autosomal dominant non-syndromic hearing loss in Koreans.BMC medical genetics · 2016Article
- Ginkgo Biloba Extract Enhances Differentiation and Performance of Neural Stem Cells in Mouse Cochlea.Cellular and molecular neurobiology · 2015Article
- Expression of EFR3A in the mouse cochlea during degeneration of spiral ganglion following hair cell loss.PloS one · 2015Article
- Clinical measures of auditory function: the cochlea and beyond.Disease-a-month : DM · 2013Review
- The cochlear implant: historical aspects and future prospects.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- TAK1 expression in the cochlea: a specific marker for adult supporting cells.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Regeneration of Hair Cells: Making Sense of All the Noise.Pharmaceuticals (Basel, Switzerland) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeTo provide an overview of the methodologies involved in the field of hair cell regeneration. First, the author provides a tutorial on the biotechnological foundations of this field to assist the reader in the comprehension and interpretation of the research involved in hair cell regeneration. Next, the author presents a review of stem cell and gene therapy and provides a critical appraisal of their application to hair cell regeneration. The methodologies used in these approaches are highlighted.
methodThe author conducted a narrative review of the fields of cellular, molecular, and developmental biology, tissue engineering, and stem cell and gene therapy using the PubMed database.
resultsThe use of biotechnological approaches to the treatment of hearing loss--approaches such as stem cell and gene therapy-has led to new methods of regenerating cochlear hair cells in mammals.
conclusionsIncredible strides have been made in assembling important pieces of the puzzle that comprise hair cell regeneration. However, mammalian hair cell regeneration using stem cell and gene therapy are years--if not decades--away from being clinically feasible. If the goals of the biological approaches are met, these therapies may represent future treatments for hearing loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.