ArticleEndocrinology2011
Androgenic influence on serotonergic activation of the HPA stress axis.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Golden window of intervention in PTSD: a synthesis of preclinical evidence.Psychopharmacology · 2026Review
- Neuroendocrine abnormalities as predictors of suicidal ideation in bipolar disorder patients during depressive episodes: a cross-sectional study.BMC psychiatry · 2025Article
- Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics.Heliyon · 2024Review
- The adipose tissue keeps the score: priming of the adrenal-adipose tissue axis by early life stress predisposes women to obesity and cardiometabolic risk.Frontiers in endocrinology · 2024Review
- Testosterone and Suicidal Behavior in Bipolar Disorder.International journal of environmental research and public health · 2023Article
- Research on Xiaoyao Powder in the treatment of depression based on epigenetics and quality markers.Frontiers in neuroscience · 2023Review
- The sex-dependent response to psychosocial stress and ischaemic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Influences of Stress and Sex on the Paraventricular Thalamus: Implications for Motivated Behavior.Frontiers in behavioral neuroscience · 2021Article
- DRUGPATH: The Drug Gene Pathway Meta-Database.International journal of molecular sciences · 2020Article
- Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.Frontiers in endocrinology · 2020Article
- Associations Between Anxiety, Body Mass Index, and Sex Hormones in Women.Frontiers in psychiatry · 2019Article
- Nanomedicine applications in women's health: state of the art.International journal of nanomedicine · 2018Review
- Modeling the Sex Differences and Interindividual Variability in the Activity of the Hypothalamic-Pituitary-Adrenal Axis.Endocrinology · 2017Article
- Sex as a Biological Variable: Who, What, When, Why, and How.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Sex differences and stress across the lifespan.Nature neuroscience · 2015Review
- Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity.Biological psychiatry · 2014Article
- Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine.Journal of neurochemistry · 2014Article
- Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis.Frontiers in neuroendocrinology · 2014Review
- Mechanisms of antidepressant resistance.Frontiers in pharmacology · 2013Review
- Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The higher incidence of stress-mediated affective disorders in women may be a function of gonadal hormone influence on complex interactions between serotonin and neural circuits that mediate the hypothalamic-pituitary-adrenal (HPA) stress axis. The paraventricular nucleus of the hypothalamus (PVN) receives serotonergic innervation, and selective serotonin reuptake inhibitors such as citalopram activate the HPA axis independent of stress. We have previously demonstrated that the magnitude of this serotonergic activation was greater in females and was attenuated by testosterone administration; however, the potential central sites of action where androgens reduce these serotonergic effects have not been determined. Therefore, we examined a time course of corticosterone production and used central c-Fos protein levels to assay neuronal activation in stress-related brain regions in female, male, and gonadectomized male mice after an acute citalopram injection (15 mg/kg). In the hippocampus, c-Fos-immunoreactivity was greater in males than in females or gonadectomized males. This same pattern emerged in the lateral septum after vehicle and gonadectomy reversed the effect of citalopram. These regions are important for inhibitory influences on the PVN, and accordingly, hippocampal c-Fos levels were negatively correlated with corticosterone production. No sex differences in c-Fos were detected in the PVN, cingulate cortex, or paraventricular thalamus in response to vehicle or citalopram. These data support brain region-specific regulation of the HPA axis where sex differences may be mediated partly through androgen enhancement of signaling in inhibitory regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.