Evidence map›Paper›PMID 21385834›Full record

ArticleAmerican journal of epidemiology2011

Ambient temperature, air pollution, and heart rate variability in an aging population.

Cizao Ren, Marie S O'Neill, Sung Kyun Park, David Sparrow, Pantel Vokonas, Joel Schwartz

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 4 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. The Mortality Effect of Apparent Temperature: A Multi-City Study in Asia.International journal of environmental research and public health · 2021
    Pooled it
  3. Pooled it
  4. Meta-Analysis of Cardiac Mortality in Three Cohorts of Carbon Black Production Workers.International journal of environmental research and public health · 2016
    Pooled it
  5. Trial
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  13. Review
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  18. Women Emotional, Cognitive and Physiological Modes of Coping with Daily Urban Environments: A Pilot Study.International journal of environmental research and public health · 2022
    Article
  19. Climatic influences on cardiovascular diseases.World journal of cardiology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cizao RenExposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, Massachusetts 02215, USA. rencizao@yahoo.com
Marie S O'Neill
Sung Kyun Park
David Sparrow
Pantel Vokonas
Joel Schwartz
Center for Environmental Health · USHarvard University Press · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Marc G Weisskopf · 1985 to 2026
$44.6M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8M
Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico CityR01ES016932 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'NEILL, MARIE SYLVIA · 2008 to 2015
$2.2M
Environment, Novel Aging Outcomes, and GeneticsK01ES016587 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARK, SUNG KYUN · 2009 to 2013
$622k
NIEHS NIH HHS ES00002NIEHS NIH HHS K01 ES016587NIEHS NIH HHS KO1-ES016587NIEHS NIH HHS P01-ES008925NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01-ES015172NIEHS NIH HHS R01 ES016932NIEHS NIH HHS R01-ES016932
6 · The paper itself

Abstract

Studies show that ambient temperature and air pollution are associated with cardiovascular disease and that they may interact to affect cardiovascular events. However, few epidemiologic studies have examined mechanisms through which ambient temperature may influence cardiovascular function. The authors examined whether temperature was associated with heart rate variability (HRV) in a Boston, Massachusetts, study population and whether such associations were modified by ambient air pollution concentrations. The population was a cohort of 694 older men examined between 2000 and 2008. The authors fitted a mixed model to examine associations between temperature and air pollution and their interactions with repeated HRV measurements, adjusting for covariates selected a priori on the basis of their previous studies. Results showed that higher ambient temperature was associated with decreases in HRV measures (standard deviation of normal-to-normal intervals, low-frequency power, and high-frequency power) during the warm season but not during the cold season. These warm-season associations were significantly greater when ambient ozone levels were higher (>22.3 ppb) but did not differ according to levels of ambient fine (≤2.5 μm) particulate matter. The authors conclude that temperature and ozone, exposures to both of which are expected to increase with climate change, might act together to worsen cardiovascular health and/or precipitate cardiovascular events via autonomic nervous system dysfunction.

Indexed as

AgedAged, 80 and overAir PollutionBostonCardiovascular DiseasesHeart RateHot TemperatureHumansLongitudinal StudiesMaleOzoneSeasonsOzone

Identifiers

PMID21385834
PMCPMC3121221
OpenAlexW2137664072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.