ArticleGenetics2011
Quantitative epigenetics through epigenomic perturbation of isogenic lines.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenomics as Potential Tools for Enhancing Magnitude of Breeding Approaches for Developing Climate Resilient Chickpea.Frontiers in genetics · 2022Pooled it
- Partial Reproducibility and Pleiotropic Epigenetic QTLs inPlants (Basel, Switzerland) · 2026Article
- Review
- Quantitative Epigenetics: A New Avenue for Crop Improvement.Epigenomes · 2020Review
- AlphaBeta: computational inference of epimutation rates and spectra from high-throughput DNA methylation data in plants.Genome biology · 2020Article
- Epigenetic mapping of theGenome research · 2019Article
- Recursive Algorithms for Modeling Genomic Ancestral Origins in a Fixed Pedigree.G3 (Bethesda, Md.) · 2018Article
- Induction of epigenetic variation in Arabidopsis by over-expression of DNA METHYLTRANSFERASE1 (MET1).PloS one · 2018Article
- A Multigenic Network of ARGONAUTE4 Clade Members Controls Early Megaspore Formation in Arabidopsis.Genetics · 2016Article
- Genetic sources of population epigenomic variation.Nature reviews. Genetics · 2016Review
- Signatures of Dobzhansky-Muller Incompatibilities in the Genomes of Recombinant Inbred Lines.Genetics · 2016Article
- Modeling X-linked ancestral origins in multiparental populations.G3 (Bethesda, Md.) · 2015Article
- Rapid evolutionary responses of life history traits to different experimentally-induced pollutions in Caenorhabditis elegans.BMC evolutionary biology · 2014Article
- A general modeling framework for genome ancestral origins in multiparental populations.Genetics · 2014Article
- A case-control design for testing and estimating epigenetic effects on complex diseases.Briefings in bioinformatics · 2014Article
- Symbiote transmission and maintenance of extra-genomic associations.Frontiers in microbiology · 2014Article
- Research progress in allele-specific expression and its regulatory mechanisms.Journal of applied genetics · 2013Review
- Epigenetics and phenotypic variability: some interesting insights from birds.Genetics, selection, evolution : GSE · 2013Review
- A quantitative genetic and epigenetic model of complex traits.BMC bioinformatics · 2012Article
- A hypomethylated population of Brassica rapa for forward and reverse epi-genetics.BMC plant biology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interindividual differences in chromatin states at a locus (epialleles) can result in gene expression changes that are sometimes transmitted across generations. In this way, they can contribute to heritable phenotypic variation in natural and experimental populations independent of DNA sequence. Recent molecular evidence shows that epialleles often display high levels of transgenerational instability. This property gives rise to a dynamic dimension in phenotypic inheritance. To be able to incorporate these non-Mendelian features into quantitative genetic models, it is necessary to study the induction and the transgenerational behavior of epialleles in controlled settings. Here we outline a general experimental approach for achieving this using crosses of epigenomically perturbed isogenic lines in mammalian and plant species. We develop a theoretical description of such crosses and model the relationship between epiallelic instability, recombination, parent-of-origin effects, as well as transgressive segregation and their joint impact on phenotypic variation across generations. In the limiting case of fully stable epialleles our approach reduces to the classical theory of experimental line crosses and thus illustrates a fundamental continuity between genetic and epigenetic inheritance. We consider data from a panel of Arabidopsis epigenetic recombinant inbred lines and explore estimates of the number of quantitative trait loci for plant height that resulted from a manipulation of DNA methylation levels in one of the two isogenic founder strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.