ArticleBMC infectious diseases2011
Reduced Dicer expression in the cord blood of infants admitted with severe respiratory syncytial virus disease.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas.International journal of genomics · 2017Article
- The role of microRNAs in respiratory viral infection: friend or foe?Reviews in medical virology · 2016Review
- Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss.Journal of Korean medical science · 2015Article
- Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Nasal mucosal microRNA expression in children with respiratory syncytial virus infection.BMC infectious diseases · 2015Article
- The Expression of AGO2 and DGCR8 in Idiopathic Sudden Sensorineural Hearing Loss.Clinical and experimental otorhinolaryngology · 2014Article
- Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor.Journal of virology · 2013Article
- Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.Molecular and cellular biology · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory syncytial virus (RSV) is one of the most important causes of pediatric hospital admissions in the developed world. The ribonuclease Dicer is an important regulator of gene expression and cellular function via RNA interference, and may also have anti-viral functions. A previous microarray analysis of the cord blood of 5 patients with RSV disease suggested downregulation of Dicer. In order to further investigate whether reduced Dicer expression can predispose newborns to RSV disease, we have analyzed the gene expression of Dicer in the cord blood of 37 infants with confirmed RSV disease.
methodsThe cord blood of 2108 newborns was collected. 51 had a positive nasopharyngeal aspirate for RSV <1 year, and were grouped according to disease severity. 37 had sufficient cord blood RNA of good quality. Dicer gene expression was assessed by qPCR analysis of cord blood using a TaqMan low-density array and compared to control infants who did not present with RSV disease using the Mann-Whitney test.
resultsThere was significant downregulation of Dicer in the severe disease group: relative quantity 0.69 (95% CI: 0.56 - 0.87), p = 0.002. There was no significant downregulation in the mild disease group.
conclusionsWe demonstrate reduced Dicer expression in the cord blood of infants with severe RSV disease, prior to RSV exposure. We theorize that this may predispose to RSV disease by disruption of leukocyte gene regulation or direct anti-viral RNA interference mechanisms.
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