ArticleBMC evolutionary biology2011
Reduced stability of mRNA secondary structure near the translation-initiation site in dsDNA viruses.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Increasing recombinant protein production in E. coli via FACS-based selection of N-terminal coding DNA libraries.The FEBS journal · 2025Article
- Synonymous variants that disrupt messenger RNA structure are significantly constrained in the human population.GigaScience · 2021Article
- Review
- Functional and Structural Consequence of Rare Exonic Single Nucleotide Polymorphisms: One Story, Two Tales.Genome biology and evolution · 2015Article
- Escherichia coli and Staphylococcus phages: effect of translation initiation efficiency on differential codon adaptation mediated by virulent and temperate lifestyles.The Journal of general virology · 2015Article
- The relationship between dN/dS and scaled selection coefficients.Molecular biology and evolution · 2015Article
- Widespread signatures of local mRNA folding structure selection in four Dengue virus serotypes.BMC genomics · 2015Article
- Multiple roles of the coding sequence 5' end in gene expression regulation.Nucleic acids research · 2015Review
- Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation.Molecular systems biology · 2014Article
- Quantifying position-dependent codon usage bias.Molecular biology and evolution · 2014Article
- The impact of RNA structure on coding sequence evolution in both bacteria and eukaryotes.BMC evolutionary biology · 2014Article
- Synonymous site conservation in the HIV-1 genome.BMC evolutionary biology · 2013Article
- Slow fitness recovery in a codon-modified viral genome.Molecular biology and evolution · 2012Article
- Reduced mRNA secondary-structure stability near the start codon indicates functional genes in prokaryotes.Genome biology and evolution · 2012Article
- Weak 5'-mRNA secondary structures in short eukaryotic genes.Genome biology and evolution · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRecent studies have demonstrated a selection pressure for reduced mRNA secondary-structure stability near the start codon of coding sequences. This selection pressure can be observed in bacteria, archaea, and eukaryotes, and is likely caused by the requirement of efficient translation initiation in cellular organism.
resultsHere, we surveyed the complete genomes of 650 dsDNA virus strains for signals of reduced stability of mRNA secondary structure near the start codon. Our analysis included viruses infecting eukaryotic, prokaryotic, and archaeic hosts. We found that many viruses showed evidence for reduced mRNA secondary-structure stability near the start codon. The effect was most pronounced in viruses infecting prokaryotes, but was also observed in viruses infecting eukaryotes and archaea. The reduction in stability generally increased with increasing genomic GC content. For bacteriophage, the reduction was correlated with a corresponding reduction of stability in the phage hosts.
conclusionsWe conclude that reduced stability of the mRNA secondary structure near the start codon is a common feature for dsDNA viruses, likely driven by the same selective pressures that cause it in cellular organisms.
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