ArticleBMC medical genetics2011
Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
Article in BMC medical genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- PARP1 as a novel therapeutic and diagnostic tool in autoimmune rheumatic diseases: a systematic literature review.Rheumatology international · 2026Pooled it
- Association of interleukin-6 promoter polymorphism with rheumatoid arthritis: a meta-analysis with trial sequential analysis.Clinical rheumatology · 2022Pooled it
- The relationship between 896A/G (rs4986790) polymorphism ofFrontiers in genetics · 2022Pooled it
- Pro-inflammatory cytokine response pre-dominates immuno-genetic pathway in development of rheumatoid arthritis.Molecular biology reports · 2020Pooled it
- Circulating interleukin-6 and rheumatoid arthritis: A Mendelian randomization meta-analysis.Medicine · 2016Pooled it
- Association between interleukin-6 gene polymorphisms and rheumatoid arthritis in Chinese Han population: a case-control study and a meta-analysis.Scientific reports · 2014Pooled it
- Association between TNF-α promoter -308 A/G polymorphism and rheumatoid arthritis: a meta-analysis.Rheumatology international · 2014Pooled it
- Inflammatory factor Interleukin-6 and its correlation with rheumatoid arthritis: A meta-analysis.Heliyon · 2024Article
- Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis.Experimental and therapeutic medicine · 2024Article
- Plasma TNF-α Elevation in Biologic Naive Rheumatoid Arthritis Patients Belonging to a Population with New Mutations in TLR4 and CYP51A1 genes without Association with Disease-Related Antibodies Levels.International journal of molecular and cellular medicine · 2024Article
- An integrated pipeline for prediction of Clostridioides difficile infection.Scientific reports · 2023Article
- Association of tumor necrosis factor-alpha promoter region gene polymorphism at positions -308G/A, -857C/T, and -863C/A with etanercept response in Iraqi rheumatoid arthritis patients.Archives of rheumatology · 2022Article
- Proinflammatory Cytokines (IL-1, -6, -8, -15, -17, -18, -23, TNF-α) Single Nucleotide Polymorphisms in Rheumatoid Arthritis-A Literature Review.International journal of molecular sciences · 2022Review
- TLR4 and TLR9 polymorphisms are not associated with either rheumatoid arthritis or systemic lupus erythematosus in Mexican patients.Molecular biology reports · 2021Article
- The relationship between periodontal status and rheumatoid arthritis - systematic review.Reumatologia · 2020Review
- Article
- Promoter polymorphism (-590, T/C) of interleukin 4 (Saudi journal of biological sciences · 2017Review
- Association of IL1Β (-511 A/C) and IL6 (-174 G > C) polymorphisms with higher disease activity and clinical pattern of psoriatic arthritis.Clinical rheumatology · 2016Article
- Genetic polymorphisms associated with the inflammatory response in bacterial meningitis.BMC medical genetics · 2015Article
- TLR2 and TLR4 in autoimmune diseases: a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious cytokines and inflammatory mediators are known to be involved in the pathogenesis of rheumatoid arthritis (RA). We hypothesized that polymorphisms in selected inflammatory response and tissue repair genes contribute to the susceptibility to and severity of RA.
methodsPolymorphisms in TNFA, IL1B, IL4, IL6, IL8, IL10, PAI1, NOS2a, C1INH, PARP, TLR2 and TLR4 were genotyped in 376 Caucasian RA patients and 463 healthy Caucasian controls using single base extension. Genotype distributions in patients were compared with those in controls. In addition, the association of polymorphisms with the need for anti-TNF-α treatment as a marker of RA severity was assessed.
resultsThe IL8 781 CC genotype was associated with early onset of disease. The TNFA -238 G/A polymorphism was differentially distributed between RA patients and controls, but only when not corrected for age and gender. None of the polymorphisms was associated with disease severity.
conclusionsWe here report an association between IL8 781 C/T polymorphism and age of onset of RA. Our findings indicate that there might be a role for variations in genes involved in the immune response and in tissue repair in RA pathogenesis. Nevertheless, additional larger genomic and functional studies are required to further define their role in RA.
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