ArticleMagnetic resonance in medicine2011
Semi-LASER localized dynamic 31P magnetic resonance spectroscopy in exercising muscle at ultra-high magnetic field.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Dynamic multivoxel-localizedNMR in biomedicine · 2018Trial
- Skeletal muscle ATP synthesis and cellular H(+) handling measured by localized (31)P-MRS during exercise and recovery.Scientific reports · 2016Trial
- Exercising calf muscle T₂∗ changes correlate with pH, PCr recovery and maximum oxidative phosphorylation.NMR in biomedicine · 2014Trial
- Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle.NMR in biomedicine · 2026Article
- A Novel 9-ChannelMagnetic resonance in medicine · 2026Article
- Article
- 3D virtual biopsy of in vivo pH and metabolism using PRESS and semi-LASER MRS of hyperpolarizedMagnetic resonance in medicine · 2025Article
- In Vivo Quantification of Creatine Kinase Kinetics in Mouse Brain UsingNMR in biomedicine · 2025Article
- Combining Dipole and Loop Coil Elements for 7 T Magnetic Resonance Studies of the Human Calf Muscle.Sensors (Basel, Switzerland) · 2024Article
- Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleavedScientific reports · 2024Article
- Article
- Oxidative capacity varies along the length of healthy human tibialis anterior.The Journal of physiology · 2018Article
- In-vivoAnalytical biochemistry · 2017Review
- Interleaved multivoxelMagnetic resonance in medicine · 2017Article
- DynamicNMR in biomedicine · 2016Article
- Comparison of muscle BOLD responses to arterial occlusion at 3 and 7 Tesla.Magnetic resonance in medicine · 2016Article
- Article
- Localized semi-LASER dynamic (31)P magnetic resonance spectroscopy of the soleus during and following exercise at 7 T.Magma (New York, N.Y.) · 2015Article
- Rapid 3D-imaging of phosphocreatine recovery kinetics in the human lower leg muscles with compressed sensing.Magnetic resonance in medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Magnetic resonance spectroscopy (MRS) can benefit from increased signal-to-noise ratio (SNR) of high magnetic fields. In this work, the SNR gain of dynamic 31P MRS at 7 T was invested in temporal and spatial resolution. Using conventional slice selective excitation combined with localization by adiabatic selective refocusing (semi-LASER) with short echo time (TE = 23 ms), phosphocreatine quantification in a 38 mL voxel inside a single exercising muscle becomes possible from single acquisitions, with SNR = 42 ± 4 in resting human medial gastrocnemius. The method was used to quantify the phosphocreatine time course during 5 min of plantar flexion exercise and recovery with a temporal resolution of 6 s (the chosen repetition time for moderate T1 saturation). Quantification of inorganic phosphate and pH required accumulation of consecutively acquired spectra when (resting) Pi concentrations were low. The localization performance was excellent while keeping the chemical shift displacement acceptably small. The SNR and spectral line widths with and without localization were compared between 3T and 7 T systems in phantoms and in vivo. The results demonstrate that increased sensitivity of ultra-high field can be used to dynamically acquire metabolic information from a clearly defined region in a single exercising muscle while reaching a temporal resolution previously available with MRS in non-localizing studies only. The method may improve the interpretation of dynamic muscle MRS data.
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