ArticleLasers in surgery and medicine2011
A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers.
Article in Lasers in surgery and medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- In vivo Raman spectroscopy for real-time biochemical assessment of tissue pathology and physiology.Nature protocols · 2026Review
- In Vivo Differentiation of Cutaneous Melanoma From Benign Nevi With Dual-Modal System of Optical Coherence Tomography and Raman Spectroscopy.Journal of biophotonics · 2025Article
- From Vibrations to Visions: Raman Spectroscopy's Impact on Skin Cancer Diagnostics.Journal of clinical medicine · 2023Review
- Integration of cellular-resolution optical coherence tomography and Raman spectroscopy for discrimination of skin cancer cells with machine learning.Journal of biomedical optics · 2023Article
- Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis.Journal of biophotonics · 2023Review
- Co-localized line-field confocal optical coherence tomography and confocal Raman microspectroscopy for three-dimensional high-resolution morphological and molecular characterization of skin tissuesBiomedical optics express · 2022Article
- Multimodal Handheld Probe for Characterizing Otitis Media - Integrating Raman Spectroscopy and Optical Coherence Tomography.Frontiers in photonics · 2022Article
- Optical coherence tomography-guided confocal Raman microspectroscopy for rapid measurements in tissues.Biomedical optics express · 2022Article
- Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications.Journal of biomedical optics · 2021Review
- Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities.Molecules (Basel, Switzerland) · 2020Review
- Deep learning architecture "LightOCT" for diagnostic decision support using optical coherence tomography images of biological samples.Biomedical optics express · 2020Article
- Photoacoustic Imaging of Tattoo Inks: Phantom and Clinical Evaluation.Applied sciences (Basel, Switzerland) · 2020Article
- Raman Spectroscopy: Guiding Light for the Extracellular Matrix.Frontiers in bioengineering and biotechnology · 2019Review
- Raman Spectroscopy and Microscopy Applications in Cardiovascular Diseases: From Molecules to Organs.Biosensors · 2018Review
- Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements.Journal of biomedical optics · 2017Article
- Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy.Sensors (Basel, Switzerland) · 2017Review
- Multimodal discrimination of immune cells using a combination of Raman spectroscopy and digital holographic microscopy.Scientific reports · 2017Article
- Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence.Biomedical optics express · 2016Article
- Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool.BMC cancer · 2016Article
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5 authors.
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Abstract
BACKGROUND AND
objectiveThe current standard for diagnosis of skin cancers is visual inspection followed by biopsy and histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions based on either morphological or biochemical features of disease. The objective of this work is to report a clinical instrument capable of both morphological and biochemical characterization of skin cancers with RS-OCT. MATERIALS AND
methodsThe portable instrument utilizes independent 785 nm RS and 1,310 nm OCT system backbones. The two modalities are integrated in a 4″ (H) × 5″(W) × 8″(L) clinical probe. The probe enables sequential acquisition of co-registered OCT and RS data sets. The axial response of the RS collection in the skin was estimated using scattering phantoms. In addition, RS-OCT data from patients with cancerous and non-cancerous lesions are reported.
resultsThe RS-OCT instrument is capable of screening areas as large as 15 mm (transverse) by 2.4 mm (in depth) at up to 8 frames/second with OCT, and identifying locations to perform RS. RS signal is collected from a 44 µm transverse spot through a depth of approximately 530 µm. RS-OCT data sets from a superficial scar and a nodular BCC are reported to demonstrate the clinical potential of the instrument.
conclusionThe RS-OCT instrument reported here is capable of morphological and biochemical characterization of cancerous skin lesions in a clinical setting. OCT can visualize microstructural irregularities and perform an initial morphological analysis of the lesion. The images can be used to guide acquisition of biochemically specific Raman spectra. The two data sets can then be evaluated with respect to one another to take advantage of the mutually complimentary nature of RS and OCT.
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