Evidence map›Paper›PMID 21384341›Full record

ReviewInternational journal of cancer2011

Looking ahead: a case for human papillomavirus testing of self-sampled vaginal specimens as a cervical cancer screening strategy.

Patti E Gravitt, Jerome L Belinson, Jorge Salmeron, Keerti V Shah

3 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in International journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03139669 nacompletednot on this mapstarted 2016, after this paper: background citation

Cultural Acceptability and Feasibility of HPV Cervical Self Collection Aided by Lay Navigators

TypeinterventionalSponsorUniversity of VirginiaRan2016 to 2019Enrolled45ConditionsHuman Papilloma VirusArmsViba collection brush
NCT03551028 nacompletednot on this mapstarted 2016, after this paper: background citation

Cultural Acceptability and Feasibility of HPV Cervical Self Collection Aided by the Mobile

TypeinterventionalSponsorUniversity of VirginiaRan2016 to 2021Enrolled33ConditionsCervical CancerArmsHPV self collection
NCT04472455 completednot on this mapstarted 2015, after this paper: background citation

Mobile High-Resolution Microendoscopy (mHRME) for the Detection of Cervical Dysplasia in El Salvador

TypeobservationalSponsorWilliam Marsh Rice UniversityRan2015 to 2019Enrolled1,827ConditionsCervical CancerArmsHRME
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 105 citations in OpenAlex.

  1. Trial
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  12. A community-based, cross-sectional study of hrHPV DNA self-sampling-based cervical cancer screening in rural Karnataka, India.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2019
    Article
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  19. Clinical significance of human papillomavirus genotyping.Journal of gynecologic oncology · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Patti E GravittDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. pgravitt@jhsph.edu
Jerome L Belinson
Jorge Salmeron
Keerti V Shah
Johns Hopkins University · USCleveland Clinic · USMexican Social Security Institute · MX

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI Richard Bruce Roden · 2003 to 2026
$53.5M
NCI NIH HHS P50 CA098252NCI NIH HHS P50 CA98252
6 · The paper itself

Abstract

Even in the era of highly effective human papillomavirus (HPV) prophylactic vaccines, substantial reduction in worldwide cervical cancer mortality will only be realized if effective early detection and treatment of the millions of women already infected and the millions who may not receive vaccination in the next decade can be broadly implemented through sustainable cervical cancer screening programs. Effective programs must meet three targets: (i) at least 70% of the targeted population should be screened at least once in a lifetime, (ii) screening assays and diagnostic tests must be reproducible and sufficiently sensitive and specific for the detection of high-grade precursor lesions (i.e., CIN21), and (iii) effective treatment must be provided. We review the evidence that HPV DNA screening from swabs collected by the women in their home or village is sufficiently sound for consideration as a primary screening strategy in the developing world, with sensitivity and specificity for detection of CIN21 as good or better than Pap smear cytology and VIA. A key feature of a self-collected HPV testing strategy (SC-HPV) is the move of the primary screening activities from the clinic to the community. Efforts to increase the affordability and availability of HPV DNA tests, community education and awareness, development of strong partnerships between community advocacy groups, health care centers and regional or local laboratories, and resource appropriate strategies to identify and treat screen-positive women should now be prioritized to ensure successful public health translation of the technologic advancements in cervical cancer prevention.

Indexed as

Early Detection of CancerSelf-ExaminationDeveloping CountriesFemaleHumansPapillomavirus InfectionsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVagina

Identifiers

PMID21384341
PMCPMC3782104
OpenAlexW2052304478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.