ArticleArthritis and rheumatism2011
A signature of aberrant immune responsiveness identifies myocardial dysfunction in rheumatoid arthritis.
Article in Arthritis and rheumatism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Novel risk factors for cardiovascular disease in rheumatoid arthritis.Immunologic research · 2013Pooled it
- Neutrophil-to-Lymphocyte Ratio and Fibroblast Growth Factor 21: Their Role in Early Cardiovascular Involvement in Rheumatoid Arthritis.Journal of clinical medicine · 2025Article
- Prevalence and factors associated with flares following COVID-19 mRNA vaccination in patients with rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: a national cohort study.Advances in rheumatology (London, England) · 2023Article
- Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Review
- Heart Failure Risk Associated With Rheumatoid Arthritis-Related Chronic Inflammation.Journal of the American Heart Association · 2020Article
- The Impact of Different Classification Criteria Sets on the Estimated Prevalence and Associated Risk Factors of Diastolic Dysfunction in Rheumatoid Arthritis.International journal of rheumatology · 2017Article
- Cytokines pre-determined by genetic factors are involved in pathogenesis of Rheumatoid arthritis.Cytokine · 2015Article
- Predictors of diastolic dysfunction in rheumatoid arthritis.Saudi medical journal · 2015Review
- Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity.Arthritis research & therapy · 2013Observational
- Acute and long-term effect of infliximab on humoral and echocardiographic parameters in patients with chronic inflammatory diseases.Clinical rheumatology · 2013Article
- Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis.Arthritis research & therapy · 2012Article
- A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis.Arthritis research & therapy · 2012Article
- Assessing immune function by profiling cytokine release from stimulated blood leukocytes and the risk of infection in rheumatoid arthritis.Clinical immunology (Orlando, Fla.) · 2011Article
- Prevalence of left ventricular dysfunction in rheumatoid arthritis.Journal of family medicine and primary careArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveHeart failure is an important cause of death in patients with rheumatoid arthritis (RA). Evidence suggests that immune mechanisms contribute to myocardial injury and fibrosis, leading to left ventricular diastolic dysfunction (LVDD). The purpose of this study was to identify a signature of LVDD in patients with RA by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo.
methodsRA patients (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild LVDD, or moderate-to-severe LVDD. The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. Logistic regression models were used to test for associations between a multicytokine immune response score and LVDD, after adjusting for clinical covariates.
resultsAn 11-cytokine profile effectively differentiated patients with moderate-to-severe LVDD from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe LVDD (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum interleukin-6 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other RA characteristics and LVDD risk factors.
conclusionThe major finding of this study was that aberrant systemic immune responsiveness is associated with advanced myocardial dysfunction in patients with RA. The unique information added by the immune response score concerning the likelihood of LVDD warrants future longitudinal studies of its value in predicting future deterioration in myocardial function.
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