Trial reportJournal of general internal medicine2011
Randomized trial of depression follow-up care by online messaging.
Trial report in Journal of general internal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Trial of Depression Care Management by Electronic Secure Messaging
Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients
Who cites it
78 citing papers in PubMed, 12 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Remote Measurement-Based Care Interventions for Mental Health: Systematic Review and Meta-Analysis.JMIR mental health · 2026Pooled it
- Nurse-led remote digital support for adults with chronic conditions: A systematic synthesis without meta-analysis.Journal of clinical nursing · 2025Pooled it
- The use of patient-reported outcome measures to improve patient-related outcomes - a systematic review.Health and quality of life outcomes · 2024Pooled it
- Effectiveness of interventions to improve medication adherence in adults with depressive disorders: a meta-analysis.BMC psychiatry · 2022Pooled it
- The Impact of Digital Patient Portals on Health Outcomes, System Efficiency, and Patient Attitudes: Updated Systematic Literature Review.Journal of medical Internet research · 2021Pooled it
- The Use and Effects of Electronic Health Tools for Patient Self-Monitoring and Reporting of Outcomes Following Medication Use: Systematic Review.Journal of medical Internet research · 2018Pooled it
- Measuring Psychiatric Symptoms Remotely: a Systematic Review of Remote Measurement-Based Care.Current psychiatry reports · 2018Pooled it
- Technology-mediated interventions for enhancing medication adherence.Journal of the American Medical Informatics Association : JAMIA · 2015Pooled it
- Patients' online access to their electronic health records and linked online services: a systematic review in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Pooled it
- Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014Pooled it
- Nurse-led interventions to enhance adherence to chronic medication: systematic review and meta-analysis of randomised controlled trials.European journal of clinical pharmacology · 2013Pooled it
- Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012Pooled it
- Trial
- Interventions to Reduce Unhealthy Alcohol Use among Primary Care Patients with HIV: the Health and Motivation Randomized Clinical Trial.Journal of general internal medicine · 2019Trial
- Blended care vs. usual care in the treatment of depressive symptoms and disorders in general practice [BLENDING]: study protocol of a non-inferiority randomized trial.BMC psychiatry · 2017Trial
- Trial
- Telephone and in-person cognitive behavioral therapy for major depression after traumatic brain injury: a randomized controlled trial.Journal of neurotrauma · 2015Trial
- Online cognitive behavioral therapy for depressed primary care patients: a pilot feasibility project.The Permanente journal · 2014Trial
- A pilot randomized controlled trial of an outreach intervention to improve depression treatment initiation among racial and ethnic groups.General hospital psychiatryTrial
- Patient and Care Team Perspectives of Barriers to and Facilitators for the Implementation of a Digital Health Program for Depression in Primary Care: Qualitative Study.Journal of medical Internet research · 2026Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundQuality of antidepressant treatment remains disturbingly poor. Rates of medication adherence and follow-up contact are especially low in primary care, where most depression treatment begins. Telephone care management programs can address these gaps, but reliance on live contact makes such programs less available, less timely, and more expensive.
objectiveEvaluate the feasibility, acceptability, and effectiveness of a depression care management program delivered by online messaging through an electronic medical record.
designRandomized controlled trial comparing usual primary care treatment to primary care supported by online care management
settingNine primary care clinics of an integrated health system in Washington state
participantsTwo hundred and eight patients starting antidepressant treatment for depression.
interventionThree online care management contacts with a trained psychiatric nurse. Each contact included a structured assessment (severity of depression, medication adherence, side effects), algorithm-based feedback to the patient and treating physician, and as-needed facilitation of follow-up care. All communication occurred through secure, asynchronous messages within an electronic medical record. MAIN MEASURES: An online survey approximately five months after randomization assessed the primary outcome (depression severity according to the Symptom Checklist scale) and satisfaction with care, a secondary outcome. Additional secondary outcomes (antidepressant adherence and use of health services) were assessed using computerized medical records. KEY
resultsPatients offered the program had higher rates of antidepressant adherence (81% continued treatment more than 3 months vs. 61%, p = 0.001), lower Symptom Checklist depression scores after 5 months (0.95 vs. 1.17, p = 0.043), and greater satisfaction with depression treatment (53% "very satisfied" vs. 33%, p = 0.004). LIMITATIONS: The trial was conducted in one integrated health care system with a single care management nurse. Results apply only to patients using online messaging.
conclusionsOur findings suggest that organized follow-up care for depression can be delivered effectively and efficiently through online messaging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.