Evidence map›Paper›PMID 21384147›Full record

ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2011

Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.

Lisa J Henderson, Lena Al-Harthi

Abstract readReview
In one paragraph

Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Interaction of viral oncogenic proteins with the Wnt signaling pathway.Iranian journal of basic medical sciences · 2018
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Nuclear translocation of β-catenin is essential for glioma cell survival.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012
    Article
  18. Wnt/β-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012
    Review
  19. Interplay between Wnt/β-catenin signaling and HIV: virologic and biologic consequences in the CNS.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lisa J HendersonDepartment of Immunology/Microbiology and Center for AIDS Research, Rush University Medical Center, Chicago, IL 60607, USA.
Lena Al-Harthi

Funding

Tissue Culture and Virology Laboratory CoreP01AI082971 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI FRENCH, AUDREY · 2009 to 2013
$11.2M
Interplay between neuroprotective pathways, HIV, and astrocytesR01NS060632 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI AL-HARTHI, LENA · 2008 to 2018
$4.9M
DevelopmentalP30AI082151 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI LANDAY, ALAN L · 2009 to 2014
$4.6M
Virus/host interaction in HIV neuropathogenesisF31NS071999 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI HENDERSON, LISA JANE · 2010 to 2012
$53k
NIAID NIH HHS P01 AI082971NIAID NIH HHS P30 AI 082151NIAID NIH HHS P30 AI082151NINDS NIH HHS F31 NS071999NINDS NIH HHS R01 NS060632
6 · The paper itself

Abstract

A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.

Indexed as

AnimalsAnti-HIV AgentsBasic Helix-Loop-Helix Leucine Zipper Transcription Factorsbeta CateninHIV-1HIV InfectionsHumansSignal TransductionTranscription Factor 4Transcription FactorsVirus ReplicationAnti-HIV AgentsBasic Helix-Loop-Helix Leucine Zipper Transcription Factorsbeta CateninTCF4 protein, humanTranscription Factor 4Transcription Factors

Identifiers

PMID21384147
PMCPMC3836044

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.