ReviewCurrent osteoporosis reports2011
Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading.
Review in Current osteoporosis reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass.BMC musculoskeletal disorders · 2016Trial
- Physical training increases osteoprotegerin in postmenopausal women.Journal of bone and mineral metabolism · 2012Trial
- Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Trial
- Associations of Handgrip Strength with Bone Health and Mental Health in Postmenopausal Women: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Exercise for optimizing bone health after hormone-induced increases in bone stiffness.Frontiers in endocrinology · 2023Review
- Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.Journal of neuroscience research · 2020Article
- Physical Activity and Bone Health: What Is the Role of Immune System? A Narrative Review of the Third Way.Frontiers in endocrinology · 2019Review
- Influence of body weight on bone mass, architecture and turnover.The Journal of endocrinology · 2016Review
- Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation.Molecules and cells · 2016Article
- Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice.Bone · 2015Article
- Different exercise modalities have distinct effects on the integrin-linked kinase (ILK) and Ca2+ signaling pathways in the male rat bone.Physiological reports · 2015Article
- Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Planar cell polarity aligns osteoblast division in response to substrate strain.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Mechanical load increases in bone formation via a sclerostin-independent pathway.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Mechanosignaling in bone health, trauma and inflammation.Antioxidants & redox signaling · 2014Review
- The role of midkine in skeletal remodelling.British journal of pharmacology · 2014Review
- The Contribution of Experimental in vivo Models to Understanding the Mechanisms of Adaptation to Mechanical Loading in Bone.Frontiers in endocrinology · 2014Review
- Osteoimmunology and bone homeostasis: relevance to spondyloarthritis.Current rheumatology reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
There appears to be no unique mechanically sensitive pathway by which changes in bone loading regulate bone mass and architecture to ensure adequate structural strength. Rather, strain-derived changes in bone cells activate a number of nonspecific strain-sensitive pathways (including calcium fluxes, prostanoids, nitric oxide, extracellular signal-regulated kinase, and sclerostin), the activities of which are modified by a number of factors (including estrogen receptors) for which this contribution is subsidiary to other purposes. The strain-sensitive pathways modified by these factors interact with a number of other pathways, some of which appear to have specific osteoregulatory potential (eg, the parathyroid hormone pathway), whereas others such as the Wnt pathway appear to be associated primarily with the response mechanisms of proliferation, differentiation, and apoptosis. The outcome of these multiple interactions are stimuli for local bone formation, resorption, or maintenance of the status quo, to maintain existing bone architecture or adapt it to a new mechanical regimen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.