ReviewCurrent gastroenterology reports2011
Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation.
Review in Current gastroenterology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.The Cochrane database of systematic reviews · 2018Pooled it
- Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.The Cochrane database of systematic reviews · 2018Pooled it
- Prevalence of constipation in cystic fibrosis patients: a systematic review of observational studies.Jornal de pediatriaPooled it
- The significant impact of meconium ileus on clinical outcomes among Brazilian individuals with cystic fibrosis-a retrospective analysis of a patient registry.Lancet regional health. Americas · 2025Article
- Complicated meconium ileus in a male neonate with cystic fibrosis: Case report.Radiology case reports · 2025Article
- Diagnosis and Management of Simple and Complicated Meconium Ileus in Cystic Fibrosis, a Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Presentation, characteristics and management of obstructive intestinal conditions in cystic fibrosis.Frontline gastroenterology · 2024Article
- Functional Consequences of CFTR Interactions in Cystic Fibrosis.International journal of molecular sciences · 2024Review
- [Update on cystic fibrosis : From neonatal screening to causal treatment].Radiologie (Heidelberg, Germany) · 2022Article
- Cftr deletion in mouse epithelial and immune cells differentially influence the intestinal microbiota.Communications biology · 2022Article
- Impact ofInternational journal of molecular sciences · 2022Review
- Article
- The first report on CFTR mutations of meconium ileus in cystic fibrosis population in Saudi Arabia: A single center review.International journal of pediatrics & adolescent medicine · 2022Article
- Understanding Cystic Fibrosis Comorbidities and Their Impact on Nutritional Management.Nutrients · 2022Review
- Cystic Fibrosis Human Organs-on-a-Chip.Micromachines · 2021Review
- Intestinal Dysbiosis in Young Cystic Fibrosis Rabbits.Journal of personalized medicine · 2021Article
- Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene.JCI insight · 2021Article
- The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients. Long-term follow-up studies show that today meconium ileus is not a risk factor for impaired nutritional status, pulmonary function, or survival. DIOS and constipation are frequently seen in cystic fibrosis patients, especially later in life; genetic, dietary, and other associations have been explored. Diagnosis of DIOS is based on suggestive symptoms, with a right lower quadrant mass confirmed on abdominal radiography, whereas symptoms of constipation are milder and of longer standing. In DIOS, early aggressive laxative treatment with oral laxatives (polyethylene glycol) or intestinal lavage with balanced osmotic electrolyte solution and rehydration is required, which now makes the need for surgical interventions rare. Constipation can generally be well controlled with polyethylene glycol maintenance treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.