Trial reportBone marrow transplantation2012
Tear physiology in dry eye associated with chronic GVHD.
Trial report in Bone marrow transplantation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Autologous platelet lysate for treatment of refractory ocular GVHD.Bone marrow transplantation · 2012Trial
- Mesenchymal stromal cells treatment attenuates dry eye in patients with chronic graft-versus-host disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Trial
- Allogeneic serum eye drops for the treatment of dry eye patients with chronic graft-versus-host disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2012Trial
- A nomogram model for predicting ocular GVHD following allo-HSCT based on risk factors.BMC ophthalmology · 2023Article
- Update on ocular graft-versus-host disease.Indian journal of ophthalmology · 2021Review
- Assessing the ocular surface microbiome in severe ocular surface diseases.The ocular surface · 2020Observational
- Clinical Analysis: Aqueous-Deficient and Meibomian Gland Dysfunction in Patients With Primary Sjogren's Syndrome.Frontiers in medicine · 2019Article
- Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjögren's syndrome.International journal of ophthalmology · 2019Article
- Multiple Natural and Experimental Inflammatory Rabbit Lacrimal Gland Phenotypes.The ocular surface · 2016Article
- Adult human mesenchymal stromal cells and the treatment of graft versus host disease.Stem cells and cloning : advances and applications · 2014Review
- Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations.Journal of ophthalmic & vision research · 2013Review
- Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation.Molecular vision · 2012Article
- Toll-like receptor 2-mediated NF-κB inflammatory responses in dry eye associated with cGVHD.Molecular vision · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to compare tear physiology characteristics of chronic GVHD (cGVHD)-associated dry eye to dry eye caused by Sjogren's syndrome (SS), a extreme form of aqueous-deficient dry eye, and meibomian gland dysfunction (MGD), the major cause of evaporative dry eye. Tear turnover rate, evaporation and osmolarity along with meibomian gland dropout and lipid layer interferometric patterns were assessed in the right eyes of 12 patients with dry eye associated with cGVHD, 12 age-matched patients with SS and 12 age-sex matched subjects with MGD. In cGVHD, the decrease in tear turnover rate was similar (P=0.33), but the number of non-functioning meibomian glands was significantly higher (P<0.01) than in SS. Tear evaporation rate in cGVHD dry eye was found to be similar to that in MGD (P=0.36) and significantly higher than in SS (P<0.01). The lipid layer was most unstable in cGVHD compared with other groups. There was no variation in tear volume across all groups. Although statistical significance was not detected, the mean tear osmolarity (333.51±14.67mOsm/L) was highest in cGVHD. Major aspects of tear physiology were severely impaired in cGVHD-associated dry eye.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.