Evidence map›Paper›PMID 21383331›Full record

Trial reportNeurology2011

Rituximab monotherapy for patients with recurrent primary CNS lymphoma.

T T Batchelor, S A Grossman, T Mikkelsen, X Ye, S Desideri, G J Lesser

2 registry-linked trialsAbstract readClinical Trial
In one paragraph

Trial report in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 97 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00072449 phase2terminatednot on this map

A Phase II Study Of Anti-CD20 Monoclonal Antibody (Rituximab) Therapy For Patients With Refractory Or Relapsed Primary CNS Lymphoma (PCNSL)

TypeinterventionalSponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsRan2004 to 2010Enrolled12ConditionsLymphomaArmsrituximab
NCT04066920 phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Clinical Efficacy and Safety of IBER Salvage Treatment Followed by Ibrutinib Maintenance for Transplant-ineligible Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma (PCNSL): a Multicenter, Single-arm, Prospective Phase II Study

TypeinterventionalSponsorDeok-Hwan YangRan2019 to 2023Enrolled30ConditionsPrimary Central Nervous System LymphomaArmsIBER salvage chemotherapy followed by ibrutinib maintenance therapy
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

T T BatchelorStephen E. and Catherine Pappas Center for Neuro-Oncology, Yawkey 9E, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA 02114, USA. tbatchelor@partners.org
S A Grossman
T Mikkelsen
X Ye
S Desideri
G J Lesser

Funding

NEW APPROACHES TO BRAIN TUMOR THERAPY CNS CONSORTIUMU01CA062475 · NCI · JOHNS HOPKINS UNIVERSITY · PI GROSSMAN, STUART A · 1994 to 2008
$5.6M
NCI NIH HHS U01 CA62475
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAged, 80 and overAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsCentral Nervous System NeoplasmsFemaleHumansKarnofsky Performance StatusLymphomaMaleMental Status ScheduleMiddle AgedOdds RatioPilot ProjectsRituximabAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsRituximab

Identifiers

PMID21383331
PMCPMC3059144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.