ArticleProceedings of the National Academy of Sciences of the United States of America2011
Temporal coding of odor mixtures in an olfactory receptor neuron.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 90 citations in OpenAlex.
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- Antennal Sensilla Basiconica Responses to Pheromones and General Odorants in Red Imported Fire Ants,Insects · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis.Pharmaceuticals (Basel, Switzerland) · 2025Review
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- Geosmin suppresses defensive behaviour and elicits unusual neural responses in honey bees.Scientific reports · 2023Article
- Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality.eLife · 2023Article
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- Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type.PLoS biology · 2022Article
- Biological constraints on configural odour mixture perception.The Journal of experimental biology · 2022Article
- Understanding responses to chemical mixtures: looking forward from the past.Chemical senses · 2022Article
- Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount.Sleep · 2021Article
- Time Course of Odor Categorization Processing.Cerebral cortex communications · 2021Article
- Olfactory systems across mosquito species.Cell and tissue research · 2021Review
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- The mosquito taste system and disease control.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most natural odors are mixtures and often elicit percepts distinct from those elicited by their constituents. This emergence of a unique odor quality has long been attributed to central processing. Here we show that sophisticated integration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila. Odor mixtures are encoded in the temporal dynamics as well as in the magnitudes of ORN responses. ORNs can respond to an inhibitory odorant with different durations depending on the level of background excitation. ORNs respond to mixtures with distinctive temporal dynamics that reflect the physicochemical properties of the constituent odorants. The insect repellent DEET (N,N-diethyl-m-toluamide), which attenuates odor responses of multiple ORNs, differs from an ORN-specific inhibitor in its effects on temporal dynamics. Our analysis reveals a means by which integration of information from odor mixtures begins in ORNs and provides insight into the contribution of inhibitory stimuli to sensory coding.
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