ArticleProceedings of the National Academy of Sciences of the United States of America2011
Golgi nucleotide sugar transporter modulates cell wall biosynthesis and plant growth in rice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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38 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- GWAS meta-analysis using a graph-based pan-genome enhanced gene mining efficiency for agronomic traits in rice.Nature communications · 2025Pooled it
- Common genetic control for grain filling duration and kernel weight in grain sorghum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- QTL mapping of fruit sugar and acid traits in the FBMC plant biology · 2026Article
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- Integrative genomic approaches to unravel genomic regions and candidate genes associated with flag leaf photosynthesis at the reproductive stage in rice.Frontiers in plant science · 2026Article
- QTL analysis of sorghum grain traits based on high-density genetic map.Journal of applied genetics · 2025Article
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- Characterization of Cell Wall Compositions of Sodium Azide-Induced Brittle Mutant Lines in IR64 Variety and Its Potential Application.Plants (Basel, Switzerland) · 2024Article
- Research Progress on Mechanical Strength of Rice Stalks.Plants (Basel, Switzerland) · 2024Review
- Meta-learning approach for bacteria classification and identification of informative genes of the3 Biotech · 2023Article
- Targeted Identification of Rice Grain-Associated Gene Allelic Variation Through Mutation Induction, Targeted Sequencing, and Whole Genome Sequencing Combined with a Mixed-Samples Strategy.Rice (New York, N.Y.) · 2022Article
- Genome-wide association study identifies a gene responsible for temperature-dependent rice germination.Nature communications · 2022Article
- The OsEIL1-OsERF115-target gene regulatory module controls grain size and weight in rice.Plant biotechnology journal · 2022Article
- Identification and Fine Mapping of the Recessive GeneInternational journal of molecular sciences · 2022Article
- Characteristics and candidate genes associated with excellent stalk strength in maize (Frontiers in plant science · 2022Article
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- Identification of Genetic Loci for Sugarcane Leaf Angle at Different Developmental Stages by Genome-Wide Association Study.Frontiers in plant science · 2022Article
- Rice Brittle Culm19 Encoding Cellulose Synthase Subunit CESA4 Causes Dominant Brittle Phenotype But has No Distinct Influence on Growth and Grain Yield.Rice (New York, N.Y.) · 2021Article
- PREMATURE SENESCENCE LEAF 50 Promotes Heat Stress Tolerance in Rice (Oryza sativa L.).Rice (New York, N.Y.) · 2021Article
- Biosynthesis and Transport of Nucleotide Sugars for Plant Hemicellulose.Frontiers in plant science · 2021Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Golgi-localized nucleotide sugar transporters (NSTs) are considered essential for the biosynthesis of wall polysaccharides and glycoproteins based on their characteristic transport of a large number of nucleotide sugars to the Golgi lumen. The lack of NST mutants in plants has prevented evaluation of this hypothesis in plants. A previously undescribed Golgi NST mutant, brittle culm14 (bc14), displays reduced mechanical strength caused by decreased cellulose content and altered wall structure, and exhibits abnormalities in plant development. Map-based cloning revealed that all of the observed mutant phenotypes result from a missense mutation in a putative NST gene, Oryza sativa Nucleotide Sugar Transporter1 (OsNST1). OsNST1 was identified as a Golgi-localized transporter by analysis of a fluorescence-tagged OsNST1 expressed in rice protoplast cells and demonstration of UDP-glucose transport activity via uptake assays in yeast. Compositional sugar analyses in total and fractionated wall residues of wild-type and bc14 culms showed a deficiency in the synthesis of glucoconjugated polysaccharides in bc14, indicating that OsNST1 supplies the glucosyl substrate for the formation of matrix polysaccharides, and thereby modulates cellulose biosynthesis. OsNST1 is ubiquitously expressed, with high expression in mechanical tissues. The inferior mechanical strength and abnormal development of bc14 plants suggest that OsNST1 has pleiotropic effects on cell wall biosynthesis and plant growth. Identification of OsNST1 has improved our understanding of how cell wall polysaccharide synthesis is regulated by Golgi NSTs in plants.
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