ArticleProceedings of the National Academy of Sciences of the United States of America2011
Uncovering the behaviors of individual cells within a multicellular microvascular community.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Falsifying computational models of endothelial cell network formation through quantitative comparison with in vitro models.PLoS computational biology · 2025Article
- Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells.eLife · 2018Article
- A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells.Biomaterials · 2018Article
- Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices.PloS one · 2017Article
- A nanobiosensor for dynamic single cell analysis during microvascular self-organization.Nanoscale · 2016Article
- Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression.PloS one · 2016Article
- Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.PLoS computational biology · 2014Article
- Article
- Geometric control of capillary architecture via cell-matrix mechanical interactions.Biomaterials · 2014Article
- Procedure for the development of multi-depth circular cross-sectional endothelialized microchannels-on-a-chip.Journal of visualized experiments : JoVE · 2013Article
- Programming in situ immunofluorescence intensities through interchangeable reactions of dynamic DNA complexes.Chembiochem : a European journal of chemical biology · 2012Article
- Three-dimensional in vitro tri-culture platform to investigate effects of crosstalk between mesenchymal stem cells, osteoblasts, and adipocytes.Tissue engineering. Part A · 2012Article
- Spatial coordination between cell and nuclear shape within micropatterned endothelial cells.Nature communications · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Although individual cells vary in behavior during the formation of tissues, the nature of such variations are largely uncharacterized. Here, we tracked the morphologies and motilities of ~300 human endothelial cells from an initial dispersed state to the formation of capillary-like structures, distilling the dynamics of tissue morphogenesis into an array of ~36,000 numerical phenotypes. Quantitative analysis of population averages revealed two previously unidentified phases in which the cells spread before forming connections with neighboring cells and where the microvascular plexus stabilized before spatially reorganizing. Analysis at the single-cell level showed that in contrast to the population-averaged behavior, most cells followed distinct temporal patterns that were not reflected in the bulk average. Interestingly, some of these behavioral patterns correlated to the cells' final structural role within the plexus. Knowledge of how individual cells or groups of cells behave enhances our understanding of how native tissues self-organize and could ultimately enable more precise approaches for engineering tissues and synthesizing multicellular communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.