Evidence map›Paper›PMID 21383101›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2011

Fetal alcohol spectrum disorders and abnormal neuronal plasticity.

Alexandre E Medina

Abstract readReview
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
11.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
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  10. Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alexandre E MedinaDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298-0709, USA. amedina@vcu.edu
Virginia Commonwealth University · US

Funding

Amplifier Replacement for Slice Electrophysiology StudiesR01AA013023 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MEDINA, ALEXANDRE ESTEVES · 2001 to 2021
$6.3M
Alcohol in Neocortex Development and PlasticityR56AA013023 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MEDINA, ALEXANDRE ESTEVES · 2005 to 2005
$335k
NIAAA NIH HHS AA-13023NIAAA NIH HHS R01 AA013023NIAAA NIH HHS R56 AA013023
6 · The paper itself

Abstract

The ingestion of alcohol during pregnancy can result in a group of neurobehavioral abnormalities collectively known as fetal alcohol spectrum disorders (FASD). During the past decade, studies using animal models indicated that early alcohol exposure can dramatically affect neuronal plasticity, an essential property of the central nervous system responsible for the normal wiring of the brain and involved in processes such as learning and memory. The abnormalities in neuronal plasticity caused by alcohol can explain many of the neurobehavioral deficits observed in FASD. Conversely, improving neuronal plasticity may have important therapeutic benefits. In this review, the author discuss the mechanisms that lead to these abnormalities and comment on recent pharmacological approaches that have been showing promising results in improving neuronal plasticity in FASD.

Indexed as

AnimalsBrainEthanolFemaleFetal Alcohol Spectrum DisordersFetusHumansNeuronal PlasticityPregnancyEthanol

Identifiers

PMID21383101
PMCPMC3337631
OpenAlexW2122058741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.