ArticleInternational journal of antimicrobial agents2011
Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients.
Article in International journal of antimicrobial agents, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
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- Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review.European journal of microbiology & immunology · 2024Review
- Functionalization of Bacterial Cellulose with the Antimicrobial Peptide KR-12 via Chimerical Cellulose-Binding Peptides.International journal of molecular sciences · 2024Article
- Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis.Nature communications · 2023Article
- Improvement of the Antibacterial Activity of Phage Lysin-Derived Peptide P87 through Maximization of Physicochemical Properties and Assessment of Its Therapeutic Potential.Antibiotics (Basel, Switzerland) · 2022Article
- Molecular detection of Metallo-Beta-Lactamase and alginate in multidrug resistanceJournal of medicine and life · 2022Article
- Resistance Is Not Futile: The Role of Quorum Sensing Plasticity inMicroorganisms · 2022Review
- Liposome-Encapsulated Tobramycin and IDR-1018 Peptide Mediated Biofilm Disruption and Enhanced Antimicrobial Activity againstPharmaceutics · 2022Article
- An Organ System-Based Synopsis ofVirulence · 2021Review
- No Correlation between Biofilm Formation, Virulence Factors, and Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2021Article
- Encapsulation of Red Propolis in Polymer Nanoparticles for the Destruction of Pathogenic Biofilms.AAPS PharmSciTech · 2020Article
- In Vitro Comparison of Antibacterial and Antibiofilm Activities of Selected Fluoroquinolones againstPathogens (Basel, Switzerland) · 2019Article
- Curcumin as a Promising Antibacterial Agent: Effects on Metabolism and Biofilm Formation inBioMed research international · 2018Article
- Peroxisome proliferator-activated receptor-γ agonists attenuate biofilm formation byFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Multidrug resistant Pseudomonas aeruginosa survey in a stream receiving effluents from ineffective wastewater hospital plants.BMC microbiology · 2016Article
- Antimicrobial activity of mul-1867, a novel antimicrobial compound, against multidrug-resistant Pseudomonas aeruginosa.Annals of clinical microbiology and antimicrobials · 2016Article
- Tobramycin and bicarbonate synergise to kill planktonicNPJ biofilms and microbiomes · 2016Article
- Biofilm Formation and Virulence Factors Among Pseudomonas aeruginosa Isolated From Burn Patients.Jundishapur journal of microbiology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Pseudomonas aeruginosa biofilms exhibit increased antimicrobial resistance compared with planktonic isolates and are implicated in the pathogenesis of both acute and chronic lung infections. Whilst antibiotic choices for both infections are based on planktonic antibiotic susceptibility results, differences in biofilm-forming ability between the two diseases have not previously been explored. The aim of this study was to compare differences in biofilm formation and antibiotic resistance of P. aeruginosa isolated from intubated patients and from patients with chronic pulmonary disease associated with cystic fibrosis (CF). The temporal evolution of antibiotic resistance in clonal P. aeruginosa strains isolated from CF patients during periods of chronic infection and acute pulmonary exacerbation was also evaluated. Biofilm formation and biofilm antibiotic susceptibilities were determined using a modified microtitre plate assay and were compared with antibiotic susceptibility results obtained using traditional planktonic culture. Clonality was confirmed using random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) analysis. Pseudomonas aeruginosa isolates collected from intubated patients produced substantially more biofilms compared with CF isolates. There was considerable heterogeneity in biofilm-forming ability amongst the CF isolates and this was unrelated to pulmonary status. Biofilm antibiotic resistance developed rapidly amongst clonal CF isolates over time, whilst traditional antibiotic resistance determined using planktonic cultures remained stable. There was a significant positive correlation between imipenem/cilastatin and ceftazidime resistance and biofilm-forming ability. The variability in biofilm-forming ability in P. aeruginosa and the rapid evolution of biofilm resistance may require consideration when choosing antibiotic therapy for newly intubated patients and CF patients.
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