ReviewInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2011
The developing oligodendrocyte: key cellular target in brain injury in the premature infant.
Review in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers.
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Who cites it
174 citing papers in PubMed, 387 citations in OpenAlex.
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- Mesenchymal Stem Cell (MSC)-based therapies for neonatal lung and brain injury - one size fits all?Molecular and cellular pediatrics · 2026Review
- Review of in vitro approaches for assessing the toxicity of chemical stressors across diverse physiological systems.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- Early-life lung injury and the developing brain: a lung-brain axis perspective on neurodevelopmental disorders.Journal of neuroinflammation · 2026Review
- [Mechanism of mesenchymal stem cell-derived exosomes in alleviating hypoxia/re-oxygenation-induced injury of oligodendrocytes].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Putative mechanisms of caffeine as a neuroprotectant in preterm infants.Pediatric research · 2026Review
- Impact of nosocomial infections on neurodevelopmental outcome and rehospitalization rate in preterm infants with birth weight below 1500 g (NINO study).Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Peculiarity of preterm neonates at 33-35 weeks gestational age with mild-to-severe hypoxic-ischaemic encephalopathy: a single-centre experience.European journal of pediatrics · 2026Article
- Metabolic Reprogramming of Oligodendrocytes in Intrauterine Growth Restriction.Developmental neuroscience · 2026Article
- Exendin-4 as a multi-target therapy for Fetal Inflammatory Response Syndrome-induced brain injury.Frontiers in neurology · 2026Review
- Small for Gestational Age and Motor Development in Children: A Narrative Review of Risk Factors, Brain Mechanisms, and Early Interventions.Developmental neuroscience · 2025Review
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- Histologic Chorioamnionitis and Neurodevelopment in Preterm Infants.JAMA network open · 2025Article
- Brain Magnetic Resonance Imaging of Children With Molybdenum Cofactor Deficiency.Journal of inherited metabolic disease · 2025Article
- The shifting landscape of the preterm brain.Neuron · 2025Review
- Epidemiology of early-onset neonatal sepsis in Qatar, 2015-2022: a multicentre retrospective cohort study.BMJ paediatrics open · 2025Article
- [Investigating the correlation between white matter injury and cerebral perfusion in preterm infants using arterial spin labeling].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- AMX0035 Mitigates Oligodendrocyte Apoptosis and Ameliorates Demyelination in MCAO Rats by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.International journal of molecular sciences · 2025Article
114 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Brain injury in the premature infant, a problem of enormous importance, is associated with a high risk of neurodevelopmental disability. The major type of injury involves cerebral white matter and the principal cellular target is the developing oligodendrocyte. The specific phase of the oligodendroglial lineage affected has been defined from study of both human brain and experimental models. This premyelinating cell (pre-OL) is vulnerable because of a series of maturation-dependent events. The pathogenesis of pre-OL injury relates to operation of two upstream mechanisms, hypoxia-ischemia and systemic infection/inflammation, both of which are common occurrences in premature infants. The focus of this review and of our research over the past 15-20 years has been the cellular and molecular bases for the maturation-dependent vulnerability of the pre-OL to the action of the two upstream mechanisms. Three downstream mechanisms have been identified, i.e., microglial activation, excitotoxicity and free radical attack. The work in both experimental models and human brain has identified a remarkable confluence of maturation-dependent factors that render the pre-OL so exquisitely vulnerable to these downstream mechanisms. Most importantly, elucidation of these factors has led to delineation of a series of potential therapeutic interventions, which in experimental models show marked protective properties. The critical next step, i.e., clinical trials in the living infant, is now on the horizon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.