ArticleNeuroscience2011
Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 41 citations in OpenAlex.
- Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment.Neuropharmacology · 2018Trial
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Early life stress paired with adolescent alcohol consumption reduces two-bottle choice alcohol consumption in mice.Alcohol, clinical & experimental research · 2025Article
- Article
- Changes in Electroencephalography Alpha Associated With Childhood Neglect and Adolescent Alcohol Use.Child maltreatment · 2023Article
- Early developmental alcohol exposure alters behavioral outcomes following adolescent re-exposure in a rat model.Alcoholism, clinical and experimental research · 2022Article
- Adolescent neuroimmune function and its interaction with alcohol.International review of neurobiology · 2022Review
- Assessment of early morning serum cortisol levels in adult male patients with alcohol-related disorders.Medical journal, Armed Forces India · 2022Article
- Alcohol Abuse and Insomnia Disorder: Focus on a Group of Night and Day Workers.International journal of environmental research and public health · 2021Article
- Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol.Neuropharmacology · 2020Review
- Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non-binge drinkers.Addiction biology · 2019Article
- Drug-induced stress responses and addiction risk and relapse.Neurobiology of stress · 2019Review
- Binge drinking in adolescence predicts an atypical cortisol stress response in young adulthood.Psychoneuroendocrinology · 2019Article
- Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes.Alcohol (Fayetteville, N.Y.) · 2018Article
- Oxytocin and vasopressin modulation of social anxiety following adolescent intermittent ethanol exposure.Psychopharmacology · 2018Article
- Effects of adolescent alcohol exposure on stress-induced reward deficits, brain CRF, monoamines and glutamate in adult rats.Psychopharmacology · 2018Article
- Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders.Neuropharmacology · 2017Review
- Adolescent binge-pattern alcohol exposure alters genome-wide DNA methylation patterns in the hypothalamus of alcohol-naïve male offspring.Alcohol (Fayetteville, N.Y.) · 2017Article
- New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis.Frontiers in cellular neuroscience · 2017Article
- Exposure to alcohol during adolescence exerts long-term effects on stress response and the adult brain stress circuits.Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adolescent alcohol exposure (AAE) may exert long-term effects on the adult brain. Here, we tested the hypothesis that the brain regions affected include the rat hypothalamic-pituitary-adrenal (HPA) axis. Specifically, we examined the consequences of AAE [postnatal days (PND) 28-42] on the HPA axis-related brain circuitry of male rats challenged with an intragastric (ig) administration of alcohol in young adulthood (PND 61-62). Adolescent rats were exposed to alcohol vapors, while controls did not receive the drug. The mean blood alcohol level in adolescence on PND 40 was 212.8±5.7 mg %. Using immunohistochemistry and in situ hybridization procedures, we measured signals for c-fos and corticotropin releasing factor (CRF) in the paraventricular nucleus (PVN) of the hypothalamus, as well as signals for c-fos and phenylethanolamine N-methyltransferase (PNMT) in the adrenergic brain stem regions (C1 and C2). PVN CRF mRNA expression was significantly blunted in AAE rats tested at PND 61-62, compared to their controls. These animals also displayed a significant increase in the mean number of PNMT-ir cells/brain stem section in the C2 area. Collectively, these results suggest that exposure to alcohol vapors during adolescence exerts long-term effects on the ability of the PVN to mount a response to an acute alcohol administration in young adulthood, possibly mediated by medullary catecholamine input to the PVN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.