ArticleBehavioural brain research2011
Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II.Molecular psychiatry · 2026Article
- Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive-Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39-PTH2R Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation.Nature communications · 2025Article
- MMP-2/9 inhibition modulates sharp wave abundance, inhibitory proteoglycan sulfation, and fear memory in juvenile zebrafish: relevance to affective disorders.Molecular psychiatry · 2025Article
- Auditory cortical neurons are recruited to encode fear signals and anxiety by neuroligin-3-mediated synapse formation.Translational psychiatry · 2025Article
- Review
- Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression.Frontiers in endocrinology · 2025Review
- Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation.Communications biology · 2024Article
- Performance in Behavioral Testing in an Animal Model of Post-Surgical Hypoparathyroidism.Journal of personalized medicine · 2024Article
- Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System.Journal of personalized medicine · 2023Review
- Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.Biology open · 2022Article
- Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2).Journal of neuroendocrinology · 2022Review
- Article
- Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex.Psychopharmacology · 2020Article
- Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Anxiety- and depression-like behavior and impaired neurogenesis evoked by peripheral neuropathy persist following resolution of prolonged tactile hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury.Frontiers in neurology · 2014Article
- The neuroendocrine functions of the parathyroid hormone 2 receptor.Frontiers in endocrinology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.