ReviewPhysiology & behavior2011
A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals.
Review in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Mechanisms of metabolic surgery effectiveness in obesity and type 2 diabetes: a puzzle with some known pieces.International journal of obesity (2005) · 2025Review
- Mechanisms through which laparoscopic sleeve gastrectomy mitigates atherosclerosis risk: a focus on visceral adipose tissue.European journal of medical research · 2025Review
- Role of the gut-brain axis in energy and glucose metabolism.Experimental & molecular medicine · 2022Review
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- An Inhibitory Circuit From Brainstem to GnRH Neurons in Male Mice: A New Role for the RFRP Receptor.Endocrinology · 2021Article
- The metabolic impact of small intestinal nutrient sensing.Nature communications · 2021Review
- Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.Brain research · 2021Article
- ThePharmacogenomics · 2019Review
- Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating.Frontiers in psychiatry · 2019Article
- Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons.Physiology & behavior · 2018Article
- A High-fat, High-sugar 'Western' Diet Alters Dorsal Striatal Glutamate, Opioid, and Dopamine Transmission in Mice.Neuroscience · 2018Article
- The Gut-Brain Axis, the Human Gut Microbiota and Their Integration in the Development of Obesity.Frontiers in physiology · 2018Review
- Expanding frontiers in weight-control research explored by young investigators.The journal of physiological sciences : JPS · 2017Review
- The Role of the Vagal Nucleus Tractus Solitarius in the Therapeutic Effects of Obesity Surgery and Other Interventional Therapies on Type 2 Diabetes.Obesity surgery · 2016Review
- Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.International journal of molecular sciences · 2016Review
- Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.eLife · 2016Article
- Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota.Cellular and molecular life sciences : CMLS · 2016Review
- Differential Expression of AMPA Subunits Induced by NMDA Intrahippocampal Injection in Rats.Frontiers in neuroscience · 2016Article
- NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.Brain research · 2015Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Glutamate is the neurotransmitter responsible for fast excitatory transmission from vagal afferents to second order neurons in the NTS. Antagonism of NMDA-type glutamate receptors in the NTS increases food intake and attenuates reduction of food intake by vagally mediated satiation signals, such as cholecystokinin. Although, the cellular location(s) of NMDA receptors that participate in satiation is uncertain, recent findings suggest that attenuation of satiation by NMDA receptor antagonists is due, at least in part, to their action on primary vagal afferents themselves. While evidence is accumulating that NMDA receptors located on vagal afferent endings in the hindbrain are involved in control of food intake, there also is preliminary evidence that peripheral NMDA receptors also may influence vagal control of food intake. Hence, NMDA receptor expression on central and perhaps peripheral vagal afferent endings could provide a parsimonious mechanism for modulation of satiation signals by endogenously released glutamate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.