ArticleDevelopmental biology2011
The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- The matrix glycoprotein Papilin maintains the haematopoietic progenitor pool in Drosophila lymph glands.Development (Cambridge, England) · 2025Article
- Wnt signaling couples G2 phase control with differentiation during hematopoiesis in Drosophila.Developmental cell · 2024Article
- Review
- Assessing the Roles of Potential Notch Signaling Components in Instructive and Permissive Pathways with Two Drosophila Pericardial Reporters.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Cbl-Associated Protein CAP contributes to correct formation and robust function of the Drosophila heart tube.PloS one · 2020Article
- Review
- Article
- Conserved signaling mechanisms in Drosophila heart development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae.Journal of visualized experiments : JoVE · 2016Article
- Genome-Wide Approaches to Drosophila Heart Development.Journal of cardiovascular development and disease · 2016Article
- Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis.Journal of cell science · 2015Article
- The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.Leukemia · 2015Article
- Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification.Development (Cambridge, England) · 2014Article
- EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior.PloS one · 2014Article
- Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function.Developmental biology · 2013Article
- Receptor tyrosine kinases in Drosophila development.Cold Spring Harbor perspectives in biology · 2013Review
- The Iroquois complex is required in the dorsal mesoderm to ensure normal heart development in Drosophila.PloS one · 2013Article
- Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway.Developmental cell · 2012Article
- TrakEM2 software for neural circuit reconstruction.PloS one · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Blood progenitors arise from a pool of pluripotential cells ("hemangioblasts") within the Drosophila embryonic mesoderm. The fact that the cardiogenic mesoderm consists of only a small number of highly stereotypically patterned cells that can be queried individually regarding their gene expression in normal and mutant embryos is one of the significant advantages that Drosophila offers to dissect the mechanism specifying the fate of these cells. We show in this paper that the expression of the Notch ligand Delta (Dl) reveals segmentally reiterated mesodermal clusters ("cardiogenic clusters") that constitute the cardiogenic mesoderm. These clusters give rise to cardioblasts, blood progenitors and nephrocytes. Cardioblasts emerging from the cardiogenic clusters accumulate high levels of Dl, which is required to prevent more cells from adopting the cardioblast fate. In embryos lacking Dl function, all cells of the cardiogenic clusters become cardioblasts, and blood progenitors are lacking. Concomitant activation of the Mitogen Activated Protein Kinase (MAPK) pathway by Epidermal Growth Factor Receptor (EGFR) and Fibroblast Growth Factor Receptor (FGFR) is required for the specification and maintenance of the cardiogenic mesoderm; in addition, the spatially restricted localization of some of the FGFR ligands may be instrumental in controlling the spatial restriction of the Dl ligand to presumptive cardioblasts.
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