ArticleMolecular microbiology2010
A backtrack-inducing sequence is an essential component of Escherichia coli σ(70)-dependent promoter-proximal pausing.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- β-CASP proteins removing RNA polymerase from DNA: when a torpedo is needed to shoot a sitting duck.Nucleic acids research · 2021Review
- Transcription complexes as RNA chaperones.Transcription · 2021Article
- Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria.Nature communications · 2021Article
- Basic mechanisms and kinetics of pause-interspersed transcript elongation.Nucleic acids research · 2021Review
- Mechanisms of Transcriptional Pausing in Bacteria.Journal of molecular biology · 2019Review
- Active site closure stabilizes the backtracked state of RNA polymerase.Nucleic acids research · 2018Article
- Article
- σ38-dependent promoter-proximal pausing by bacterial RNA polymerase.Nucleic acids research · 2017Article
- A link between transcription fidelity and pausing in vivo.Transcription · 2017Article
- A universal transcription pause sequence is an element of initiation factor σ70-dependent pausing.Nucleic acids research · 2016Article
- Article
- Two transcription pause elements underlie a σ70-dependent pause cycle.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Regulation of promoter-proximal transcription elongation: enhanced DNA scrunching drives λQ antiterminator-dependent escape from a σ70-dependent pause.Nucleic acids research · 2014Article
- Distinct functions of the RNA polymerase σ subunit region 3.2 in RNA priming and promoter escape.Nucleic acids research · 2014Article
- Transcription elongation. Heterogeneous tracking of RNA polymerase and its biological implications.Transcription · 2014Review
- Article
- Structural transitions in the transcription elongation complexes of bacterial RNA polymerase during σ-dependent pausing.Nucleic acids research · 2012Article
- Factor-independent transcription pausing caused by recognition of the RNA-DNA hybrid sequence.The EMBO journal · 2012Article
- Transcription factor GreA contributes to resolving promoter-proximal pausing of RNA polymerase in Bacillus subtilis cells.Journal of bacteriology · 2011Article
- Initial transcribed region sequences influence the composition and functional properties of the bacterial elongation complex.Genes & development · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA polymerase of both bacteria and eukaryotes can stall or pause within tens of base pairs of its initiation site at the promoter, a state that may reflect important regulatory events in early transcription. In the bacterial model system, the σ(70) initiation factor stabilizes such pauses by binding a downstream repeat of a promoter segment, especially the '-10' promoter element. We first show here that the '-35' promoter element also can stabilize promoter-proximal pausing, through interaction with σ(70) region 4. We further show that an essential element of either type of pause is a sequence just upstream of the site of pausing that stabilizes RNA polymerase backtracking. Although the pause is not intrinsically backtracked, we suggest that the same sequence element is required both to stabilize the paused state and to potentiate backtracking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.