ArticleJournal of abnormal psychology2011
Interaction between the DRD4 VNTR polymorphism and proximal and distal environments in alcohol dependence during emerging and young adulthood.
Article in Journal of abnormal psychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Differences in cortical morphology and child internalizing or externalizing problems: Accounting for the co-occurrence.JCPP advances · 2022Article
- Interaction Effects between the Cumulative Genetic Score and Psychosocial Stressor on Self-Reported Drinking Urge and Implicit Attentional Bias for Alcohol: A Human Laboratory Study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- The interaction between the dopamine receptor D4 (DRD4) variable number tandem repeat polymorphism and perceived peer drinking norms in adolescent alcohol use and misuse.Development and psychopathology · 2017Article
- The effects of alcohol on emotion in social drinkers.Behaviour research and therapy · 2017Review
- Genetic Modification of the Relationship between Parental Rejection and Adolescent Alcohol Use.Alcohol and alcoholism (Oxford, Oxfordshire) · 2016Article
- Differential susceptibility to environmental influences: Interactions between child temperament and parenting in adolescent alcohol use.Development and psychopathology · 2016Article
- Interactions between DRD4 and developmentally specific environments in alcohol-dependence symptoms.Journal of abnormal psychology · 2015Article
- DRD4 and susceptibility to peer influence on alcohol use from adolescence to adulthood.Drug and alcohol dependence · 2014Article
- The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?Clinical psychological science : a journal of the Association for Psychological Science · 2014Article
- The developmental psychopathology of alcohol use and alcohol disorders: research achievements and future directions.Development and psychopathology · 2013Review
- Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.Alcoholism, clinical and experimental research · 2013Article
- Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism.PloS one · 2013Article
- The genetics of alcohol dependence: advancing towards systems-based approaches.Drug and alcohol dependence · 2012Review
- Article
- Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders.Medical science monitor : international medical journal of experimental and clinical research · 2011Review
- Associations Between a Dopamine D4 Receptor Gene, Alcohol Use, and Sexual Behaviors among Female Adolescent African Americans.Journal of HIV/AIDS & social servicesArticle
- Adverse Childhood Experiences and the Presence of Cancer Risk Factors in Adulthood: A Scoping Review of the Literature From 2005 to 2015.Journal of pediatric nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The manifestation of alcohol dependence at different developmental stages may be associated with different genetic and environmental factors. Taking a developmental approach, we characterized interaction between the dopamine receptor 4 variable number tandem repeat (DRD4 VNTR) polymorphism and developmentally specific environmental factors (childhood adversity, college/Greek organization involvement, and delayed adult role transition) on alcohol dependence during emerging and young adulthood. Prospective data were obtained from a cohort of 234 White individuals (56% women, 44% men) who were followed up at ages 18 through 34. A longitudinal hierarchical factor model was estimated to model a traitlike persistent alcohol dependence factor throughout emerging and young adulthood and 2 residual statelike alcohol dependence factors limited to emerging adulthood and young adulthood, respectively. We accounted for those alcohol dependence factors by modeling 3 two-way interaction effects between the DRD4 VNTR polymorphism and the 3 developmentally specific environment factors. Carriers of the DRD4 long allele showed greater susceptibility to environmental effects; they showed more persistent symptoms of alcohol dependence as childhood adversity increased and more alcohol dependence symptoms limited to emerging adulthood as college/Greek organization involvement increased. Alcohol dependence among noncarriers of the long allele, however, did not differ as a function of those environments. Although replication is necessary, these findings highlight the importance of repeated phenotypic assessments across development and modeling both distal and proximal environments and their interaction with genetic susceptibility at specific developmental stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.