ArticleJournal of cellular biochemistry2011
Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation.
Article in Journal of cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass viaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Sexual dimorphism through androgen signaling; from external genitalia to muscles.Frontiers in endocrinology · 2022Review
- Effect ofFrontiers in pharmacology · 2020Review
- Review
- The Aging Overactive Bladder: A Review of Aging-Related Changes from the Brain to the Bladder.Current bladder dysfunction reports · 2017Article
- Nutrition, Pharmacological and Training Strategies Adopted by Six Bodybuilders: Case Report and Critical Review.European journal of translational myology · 2017Article
- The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells.Stem cells international · 2016Review
- The complex and multifactorial relationship between testosterone deficiency (TD), obesity and vascular disease.Reviews in endocrine & metabolic disorders · 2015Review
- Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome.Diabetes · 2014Review
- Association of inflammaging (inflammation + aging) with higher prevalence of OAB in elderly population.International urology and nephrology · 2014Article
- Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females.Endocrinology · 2014Article
- Adipocytes in skin health and disease.Cold Spring Harbor perspectives in medicine · 2014Review
- Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation.Steroids · 2013Article
- Article
- Adipogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions.Cellular and molecular life sciences : CMLS · 2012Review
- Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes.Journal of cellular biochemistry · 2011Article
- Article
- Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Androgens regulate body composition in youth and declining testosterone that occurs with aging is associated with muscle wasting, increased fat mass and osteopenia. Transgenic mice with targeted androgen receptor (AR) over-expression in mesenchymal stem cells (MSC) were generated to explore the role of androgen signaling in the regulation of body composition. Transgenic males, but not females, were shorter and have reduced body weight and visceral fat accumulation. Dual-energy X-ray absorptiometry (DXA) revealed significant reductions in fat mass with a reciprocal increase in lean mass, yet no difference in food consumption or locomotor activity was observed. Adipose tissue weight was normal in brown fat but reduced in both gonadal and perirenal depots, and reduced hyperplasia was observed with smaller adipocyte size in visceral and subcutaneous white adipose tissue. Although serum leptin, adiponectin, triglyceride, and insulin levels were no different between the genotypes, intraperitoneal glucose tolerance testing (IPGTT) showed improved glucose clearance in transgenic males. High levels of the AR transgene are detected in MSCs but not in mature fat tissue. Reduced fibroblast colony forming units indicate fewer progenitor cells resident in the marrow in vivo. Precocious expression of glucose transporter 4 (GLUT4), peroxisome proliferator-activated receptor γ (PPARγ), and CCAAT enhancer-binding protein α (C/EBPα) was observed in proliferating precursor cultures from transgenic mice compared to controls. In more mature cultures, there was little difference between the genotypes. We propose a mechanism where enhanced androgen sensitivity can alter lineage commitment in vivo to reduce progenitor number and fat development, while increasing the expression of key factors to promote smaller adipocytes with improved glucose clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.