ArticleThe Journal of membrane biology2011
Diffusion-weighted MRI for verification of electroporation-based treatments.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Diffusion MRI biomarkers predict the outcome of irreversible electroporation in a pancreatic tumor mouse model.American journal of cancer research · 2018Article
- Irreversible Electroporation for the Ablation of Renal Cell Carcinoma: A Prospective, Human, In Vivo Study Protocol (IDEAL Phase 2b).JMIR research protocols · 2017Article
- Local Ablative Strategies for Ductal Pancreatic Cancer (Radiofrequency Ablation, Irreversible Electroporation): A Review.Gastroenterology research and practice · 2016Review
- Detection of electroporation-induced membrane permeabilization states in the brain using diffusion-weighted MRI.Acta oncologica (Stockholm, Sweden) · 2015Article
- Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation.Nanomedicine (London, England) · 2014Article
- Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors.Medical & biological engineering & computing · 2012Review
- MRI study on reversible and irreversible electroporation induced blood brain barrier disruption.PloS one · 2012Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical electroporation (EP) is a rapidly advancing treatment modality that uses electric pulses to introduce drugs or genes into, e.g., cancer cells. The indication of successful EP is an instant plasma membrane permeabilization in the treated tissue. A noninvasive means of monitoring such a tissue reaction represents a great clinical benefit since, in case of target miss, retreatment can be performed immediately. We propose diffusion-weighted magnetic resonance imaging (DW-MRI) as a method to monitor EP tissue, using the concept of the apparent diffusion coefficient (ADC). We hypothesize that the plasma membrane permeabilization induced by EP changes the ADC, suggesting that DW-MRI constitutes a noninvasive and quick means of EP verification. In this study we performed in vivo EP in rat brains, followed by DW-MRI using a clinical MRI scanner. We found a pulse amplitude-dependent increase in the ADC following EP, indicating that (1) DW-MRI is sensitive to the EP-induced changes and (2) the observed changes in ADC are indeed due to the applied electric field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.