ArticleExperimental brain research2011
Virtual labyrinth model of vestibular afferent excitation via implanted electrodes: validation and application to design of a multichannel vestibular prosthesis.
Article in Experimental brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- A Biophysical Model for Simultaneous Cochlear and Vestibular Nerve Stimulation: Insights into Neural Activation and Crosstalk in Inner Ear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Effects of Electrode Position on Vestibular Implant Performance in Rhesus Macaque.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Vestibular electrode position stability over time.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Binocular 3-D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation.Journal of neurophysiology · 2023Article
- Computer Simulation of the Electrical Stimulation of the Human Vestibular System: Effects of the Reactive Component of Impedance on Voltage Waveform and Nerve Selectivity.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Experimental Validation of a Three-Dimensional Heat Transfer Model Within the Scala Tympani With Application to Magnetic Cochlear Implant Surgery.IEEE transactions on bio-medical engineering · 2021Article
- Predicting Response of Spontaneously Firing Afferents to Prosthetic Pulsatile Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans.Journal of neural engineering · 2020Article
- Binocular 3D otolith-ocular reflexes: responses of chinchillas to prosthetic electrical stimulation targeting the utricle and saccule.Journal of neurophysiology · 2020Article
- Virtual Rhesus Labyrinth Model Predicts Responses to Electrical Stimulation Delivered by a Vestibular Prosthesis.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Milestones in the development of a vestibular implant.Current opinion in neurology · 2019Review
- Model-Based Vestibular Afferent Stimulation: Evaluating Selective Electrode Locations and Stimulation Waveform Shapes.Frontiers in neuroscience · 2018Article
- Model-based Vestibular Afferent Stimulation: Modular Workflow for Analyzing Stimulation Scenarios in Patient Specific and Statistical Vestibular Anatomy.Frontiers in neuroscience · 2017Article
- Characterization of Cochlear, Vestibular and Cochlear-Vestibular Electrically Evoked Compound Action Potentials in Patients with a Vestibulo-Cochlear Implant.Frontiers in neuroscience · 2017Article
- The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans.Frontiers in systems neuroscience · 2014Article
- Directional plasticity rapidly improves 3D vestibulo-ocular reflex alignment in monkeys using a multichannel vestibular prosthesis.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Safe direct current stimulation to expand capabilities of neural prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2013Article
- Progress toward development of a multichannel vestibular prosthesis for treatment of bilateral vestibular deficiency.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- Restoring the 3D vestibulo-ocular reflex via electrical stimulation: the Johns Hopkins multichannel vestibular prosthesis project.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
To facilitate design of a multichannel vestibular prosthesis that can restore sensation to individuals with bilateral loss of vestibular hair cell function, we created a virtual labyrinth model. Model geometry was generated through 3-dimensional (3D) reconstruction of microMRI and microCT scans of normal chinchillas (Chinchilla lanigera) acquired with 30-48 μm and 12 μm voxels, respectively. Virtual electrodes were positioned based on anatomic landmarks, and the extracellular potential field during a current pulse was computed using finite element methods. Potential fields then served as inputs to stochastic, nonlinear dynamic models for each of 2,415 vestibular afferent axons with spiking dynamics based on a modified Smith and Goldberg model incorporating parameters that varied with fiber location in the neuroepithelium. Action potential propagation was implemented by a well validated model of myelinated fibers. We tested the model by comparing predicted and actual 3D angular vestibulo-ocular reflex (aVOR) axes of eye rotation elicited by prosthetic stimuli. Actual responses were measured using 3D video-oculography. The model was individualized for each animal by placing virtual electrodes based on microCT localization of real electrodes. 3D eye rotation axes were predicted from the relative proportion of model axons excited within each of the three ampullary nerves. Multiple features observed empirically were observed as emergent properties of the model, including effects of active and return electrode position, stimulus amplitude and pulse waveform shape on target fiber recruitment and stimulation selectivity. The modeling procedure is partially automated and can be readily adapted to other species, including humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.