ArticleSurgical and radiologic anatomy : SRA2011
Early fetal development of the human cerebellum.
Article in Surgical and radiologic anatomy : SRA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- YAP/TAZ-associated cell signaling - at the crossroads of cancer and neurodevelopmental disorders.Frontiers in cell and developmental biology · 2025Review
- Neuromorphological Atlas of Human Prenatal Brain Development: White Paper.Life (Basel, Switzerland) · 2023Article
- A rare additional lobe of cerebellum, projecting from its superior surface.Anatomy & cell biology · 2022Article
- The Developing Cerebellum as a Target for Toxic Substances: Protective Role of Antioxidants.Cerebellum (London, England) · 2021Review
- Brain Development From Newborn to Adolescence: Evaluation by Neurite Orientation Dispersion and Density Imaging.Frontiers in human neuroscience · 2021Article
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- Variation of the slope of the tentorium during childhood.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Periconception Maternal Folate Status and Human Embryonic Cerebellum Growth Trajectories: The Rotterdam Predict Study.PloS one · 2015Article
- Novel patterns for the growing main bronchi in the human fetus: an anatomical, digital and statistical study.Surgical and radiologic anatomy : SRA · 2014Article
- Cellular commitment in the developing cerebellum.Frontiers in cellular neuroscience · 2014Review
- Morphometric study of the T6 vertebra and its three ossification centers in the human fetus.Surgical and radiologic anatomy : SRA · 2013Article
- Early fetal development of the human vertebral artery especially at and above the occipitovertebral junction.Surgical and radiologic anatomy : SRA · 2013Article
- Cross-sectional study of the neural ossification centers of vertebrae C1-S5 in the human fetus.Surgical and radiologic anatomy : SRA · 2013Article
- Cross-sectional study of the ossification center of the C1-S5 vertebral bodies.Surgical and radiologic anatomy : SRA · 2013Article
- New anatomical data on the growing C4 vertebra and its three ossification centers in human fetuses.Surgical and radiologic anatomy : SRA · 2013Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early cerebellum development in humans is poorly understood. The present study histologically examined sections from 20 human embryos and fetuses at 6 weeks (12-16 mm crown-rump length (CRL); 4 specimens), 7-9 weeks (21-39 mm CRL; 8 specimens), 11-12 weeks (70-90 mm CRL; 4 specimens) and 15-16 weeks (110-130 mm CRL; 4 specimens). During 7-9 weeks (approximate CRL 28 mm), the rhombic lip (a pair of thickenings of the alar plate) protruded dorsally, bent laterally, extended ventrolaterally and fused with the medially located midbrain. During that process, the primitive choroid plexus appeared to become involved in the cerebellar hemisphere to form a centrally located eosinophilic matrix. At that stage, the inferior olive had already developed in the thick medulla. Thus, the term 'bulbo-pontine extension' may represent an erroneous labeling of a caudal part of the rhombic lip. The cerebellar vermis developed much later than the hemisphere possibly from a midline dark cell cluster near the aqueduct. In the midline area after 12 weeks (80 mm CRL), the growing bilateral hemispheres seem to provide mechanical stress such as rotation and shear that cause the development of several fissures much deeper than those on the hemisphere. The rapidly growing surface germinal layer may be a minor contributor to this vermian fissure formation. The vermian fissures seem to enable inside involvement of the surface germinal cells, and to induce cytodifferentiation of the vermis. Consequently, in the early stages, it appears that the cerebellar hemisphere and vermis develop independently of each other.
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