ReviewProtein & cell2011
LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.
Review in Protein & cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet-Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition.Molecular carcinogenesis · 2026Article
- RBMS3, a downstream target of AMPK, Exerts Inhibitory Effects on Invasion and Metastasis of Lung Cancer.Journal of Cancer · 2023Article
- Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.Frontiers in pharmacology · 2023Article
- LKB1: Can We Target an Hidden Target? Focus on NSCLC.Frontiers in oncology · 2022Review
- Genomic landscape of lung adenocarcinomas in different races.Frontiers in oncology · 2022Article
- STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation andCancer research · 2021Article
- Review
- Notch Transduction in Non-Small Cell Lung Cancer.International journal of molecular sciences · 2020Review
- Liver kinase B1 correlates with prognosis and epithelial-mesenchymal transition of resectable early stage non-small cell lung cancer.Translational cancer research · 2020Article
- Application of targeted next generation sequencing for the mutational profiling of patients with acute lymphoblastic leukemia.Journal of medical biochemistry · 2020Article
- Comparative analysis of co-occurring mutations of specific tumor suppressor genes in lung adenocarcinoma between Asian and Caucasian populations.Journal of cancer research and clinical oncology · 2019Article
- Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach.Journal of experimental & clinical cancer research : CR · 2018Article
- Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner.Oncology letters · 2018Article
- Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells.Oncology reports · 2018Article
- Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.Cancer control : journal of the Moffitt Cancer Center · 2016Article
- Article
- A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2016Article
- Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1.Oncogenesis · 2015Article
- Liver kinase B1 promoter CpG island methylation is related to lung cancer and smoking.International journal of clinical and experimental medicine · 2015Article
- C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma.World journal of clinical oncology · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is featured with high mortality, with a 15% five-year survival rate worldwide. Genetic alterations, such as loss of function of tumor suppressor genes, frequently contribute to lung cancer initiation, progression and metastasis. Liver kinase B1 (LKB1), as a serine/threonine kinase and tumor suppressor, is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process, especially lung cancer progression and metastasis. This review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis, emphasizing on LKB1 downstream signaling pathways and biological functions. We will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.