ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2011
Systems biology approach to Wilson's disease.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- Relative exchangeable copper: A highly specific and sensitive biomarker for Wilson disease diagnosis.JHEP reports : innovation in hepatology · 2025Article
- [Progress on the research of hepatolenticular degeneration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
- Histological features of liver disease development in the Atp7bJournal of clinical pathology · 2024Article
- Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases.Biological trace element research · 2024Review
- Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease.Molecular neurobiology · 2024Review
- Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources.EFSA journal. European Food Safety Authority · 2023Article
- Effect of Copper and Selenium Supplementation on the Level of Elements in Rats' Femurs under Neoplastic Conditions.Nutrients · 2022Article
- InfantileJPGN reports · 2021Article
- Study on the Molecular Mechanisms Against Human Breast Cancer from Insight of Elemental Distribution in Tissue Based on Laser-Induced Breakdown Spectroscopy (LIBS).Biological trace element research · 2021Article
- Copper Toxicity Is Not Just Oxidative Damage: Zinc Systems and Insight from Wilson Disease.Biomedicines · 2021Review
- Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cardiac and autonomic function in patients with Wilson's disease.Orphanet journal of rare diseases · 2019Article
- Altered zinc balance in the Atp7bMetallomics : integrated biometal science · 2018Article
- Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Methanobactin reverses acute liver failure in a rat model of Wilson disease.The Journal of clinical investigation · 2016Article
- Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson's Disease.Journal of the American Chemical Society · 2016Article
- Wilson's disease: a comprehensive review of the molecular mechanisms.International journal of molecular sciences · 2015Review
- Copper: toxicological relevance and mechanisms.Archives of toxicology · 2014Review
- Congential scoliosis in Wilson's disease: case report and review of the literature.BMC surgery · 2014Review
- Links between copper and cholesterol in Alzheimer's disease.Frontiers in physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Wilson's disease (WD) is a severe disorder of copper misbalance, which manifests with a wide spectrum of liver pathology and/or neurologic and psychiatric symptoms. WD is caused by mutations in a gene encoding a copper-transporting ATPase ATP7B and is accompanied by accumulation of copper in tissues, especially in the liver. Copper-chelation therapy is available for treatment of WD symptoms and is often successful, however, significant challenges remain with respect to timely diagnostics and treatment of the disease. The lack of genotype-phenotype correlation remains unexplained, the causes of fulminant liver failure are not known, and the treatment of neurologic symptoms is only partially successful, underscoring the need for better understanding of WD mechanisms and factors that influence disease manifestations. Recent gene and protein profiling studies in animal models of WD began to uncover cellular processes that are primarily affected by copper accumulation in the liver. The results of such studies, summarized in this review, revealed new molecular players and pathways (cell cycle and cholesterol metabolism, mRNA splicing and nuclear receptor signaling) linked to copper misbalance. A systems biology approach promises to generate a comprehensive view of WD onset and progression, thus helping with a more fine-tune treatment and monitoring of the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.